Ghafouri-Fard Soudeh, Niazi Vahid, Taheri Mohammad, Basiri Abbas
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Front Cell Dev Biol. 2021 Apr 9;9:649115. doi: 10.3389/fcell.2021.649115. eCollection 2021.
Hematopoietic stem cells (HSCs) are a group of cells being produced during embryogenesis to preserve the blood system. They might also be differentiated to non-hematopoietic cells, including neural, cardiac and myogenic cells. Therefore, they have vast applications in the treatment of human disorders. Considering the restricted quantities of HSCs in the umbilical cord blood, inadequate mobilization of bone marrow stem cells, and absence of ethnic dissimilarity, expansion of these HSCs is an applicable method for obtaining adequate amounts of HSCs. Several molecules such as NR-101, zVADfmk, zLLYfmk, Nicotinamide, Resveratrol, the Copper chelator TEPA, dmPGE2, Garcinol, and serotonin have been used in combination of cytokines to expand HSCs . The most promising results have been obtained from cocktails that influence multipotency and self-renewal features from different pathways. In the current manuscript, we provide a concise summary of the effects of diverse small molecules on expansion of cord blood HSCs.
造血干细胞（HSCs）是一组在胚胎发育过程中产生以维持血液系统的细胞。它们也可能分化为非造血细胞，包括神经细胞、心肌细胞和成肌细胞。因此，它们在治疗人类疾病方面有广泛应用。考虑到脐带血中造血干细胞数量有限、骨髓干细胞动员不足以及不存在种族差异，扩增这些造血干细胞是获得足够数量造血干细胞的一种可行方法。几种分子，如NR-101、zVADfmk、zLLYfmk、烟酰胺、白藜芦醇、铜螯合剂TEPA、dmPGE2、藤黄菌素和血清素，已与细胞因子联合用于扩增造血干细胞。最有前景的结果来自于能从不同途径影响多能性和自我更新特性的鸡尾酒疗法。在本手稿中，我们简要总结了不同小分子对脐带血造血干细胞扩增的影响。
