Mizoguchi M, Matsuki K, Mochizuki M, Watanabe R, Ogawa K, Harada S, Hino H, Amagai M, Juji T
Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan.
Arch Dermatol. 1988 Jul;124(7):1069-73.
A 41-year-old man with Sweet's syndrome (SS) had symptoms similar to Behçet's disease (BD). To study the relationship of the two diseases, human leukocyte antigen (HLA) typing was performed on 28 patients with SS and 49 patients with BD. Of the 28 patients with SS, seven had BD symptoms. The frequencies of both HLA-B51 and -DQw3 were significantly higher in patients with BD. However, the frequencies of the two HLA antigens in the 28 patients with SS and the 21 patients with SS without BD symptoms were not significantly different from the controls. The frequency of HLA-Bw54 was significantly increased in both groups of patients with SS. Taken together, these data indicate that SS is a genetically distinct disease entity from BD, although their symptoms are similar and the incidence of SS among patients with BD is high in Japan.
一名患有斯威特综合征（SS）的41岁男性出现了与白塞病（BD）相似的症状。为研究这两种疾病的关系，对28例SS患者和49例BD患者进行了人类白细胞抗原（HLA）分型。在28例SS患者中，有7例出现了BD症状。BD患者中HLA - B51和 - DQw3的频率均显著更高。然而，28例SS患者以及21例无BD症状的SS患者中这两种HLA抗原的频率与对照组相比无显著差异。SS患者两组中HLA - Bw54的频率均显著升高。综上所述，这些数据表明，尽管SS和BD症状相似且在日本BD患者中SS的发病率较高，但SS是一种与BD在遗传上不同的疾病实体。
