Manfredini Marco, Guida Stefania, Giovani Matteo, Lippolis Nicola, Spinas Enrico, Farnetani Francesca, Dattola Annunziata, Di Matteo Eleonora, Pellacani Giovanni, Giannetti Luca
Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.
Department of Surgical Sciences, University of Cagliari, Cagliari, Italy.
Dermatol Pract Concept. 2021 Sep 1;11(4):e2021099. doi: 10.5826/dpc.1104a99. eCollection 2021 Sep.
Recurrent aphthous stomatitis consists of the presence of abrasions or ulcerations located on mucosae (oral or genital).
The aim of this article is to review the current literature providing the main causes related to recurrent aphthous stomatitis and insights into treatment and management of this clinical condition.
Articles matching terms that correlated with "recurrent aphthous stomatitis" were searched on PubMed, EMBASE, and Cochrane Library and selected according to their pertinence.
Several forms of aphthous stomatitis have been described, based on the extent (minor, major), morphology (herpetiform) and associations to other signs (Behçet syndrome or more complex inflammatory syndromes). Topical as well as systemic treatments have been described to obtain a faster remission of the aphthosis or to reduce associated symptoms such as pain.
Recurrent aphthous stomatitis can have a mild-to-severe clinical appearance, being mainly localized on the oral mucosa or at the level of the genital area. Different strategies have been described so far for its management and treatment.
复发性阿弗他口炎表现为黏膜（口腔或生殖器）出现擦伤或溃疡。
本文旨在综述当前文献，阐述与复发性阿弗他口炎相关的主要病因，并深入探讨该临床病症的治疗与管理。
在PubMed、EMBASE和Cochrane图书馆中检索与“复发性阿弗他口炎”相关的术语匹配的文章，并根据相关性进行筛选。
根据溃疡范围（轻度、重度）、形态（疱疹样）以及与其他体征的关联（白塞病或更复杂的炎症综合征），已描述了多种形式的阿弗他口炎。已描述了局部和全身治疗方法，以更快地缓解口疮或减轻相关症状，如疼痛。
复发性阿弗他口炎的临床表现可轻可重，主要局限于口腔黏膜或生殖器部位。迄今为止，已描述了不同的管理和治疗策略。
