Zorba Matina, Melidou Angeliki, Patsatsi Aikaterini, Ioannou Eleftheria, Kolokotronis Alexandros
Department of Oral Medicine and Maxillofacial Pathology, School of Dentistry, Aristotle University of Thessaloniki, Greece.
Department of Microbiology, Faculty of Medicine, Aristotle University of Thessaloniki, Greece.
Int J Womens Dermatol. 2020 Aug 4;6(5):357-364. doi: 10.1016/j.ijwd.2020.07.011. eCollection 2020 Dec.
The human microbiome refers to the entire habitat, including microorganisms, their genomes and the surrounding environmental conditions of the microbial ecosystem. When the equilibrium between microbial habitats and host is disturbed, dysbiosis is caused. The oral microbiome (OMB) has been implicated in the manifestation of many intra- and extraoral diseases. Lately, there has been an intense effort to investigate and specify the relationship between microbial complexes, especially that of the oral cavity and intestine and autoimmunity. This study aimed to review the current literature about the possible role of the OMB in the pathogenesis of autoimmune diseases.
We searched for published articles in English indexed in PubMed, Medline, Research Gate and Google Scholar using a search strategy that included terms for oral microbiome, autoimmune diseases, dysbiosis and next-generation sequencing.
An important number of articles were gathered and used for the description of the possible impact of dysbiosis of OMB in the pathogenesis of Sjögren's syndrome, systemic lupus erythematosus, rheumatoid arthritis, Behcet's disease, Crohn's disease and psoriasis.
This review article draws attention to the relationship between OMB and the triggering of a number of autoimmune diseases. Although this specific topic has been previously reviewed, herein, the authors review recent literature regarding the full list of nosological entities related to the OMB, point out the interaction between the microbiome and sex hormones with regard to their role in autoimmunity and discuss novel and promising therapeutic approaches for systemic autoimmune diseases. Furthermore, the question arises of whether the OMB is associated with oral bullous autoimmune diseases.
人类微生物组是指整个栖息地，包括微生物、它们的基因组以及微生物生态系统的周围环境条件。当微生物栖息地与宿主之间的平衡受到干扰时，就会导致生态失调。口腔微生物组（OMB）与许多口腔内和口腔外疾病的表现有关。最近，人们一直在努力研究并明确微生物复合体之间的关系，尤其是口腔和肠道微生物复合体与自身免疫之间的关系。本研究旨在综述当前关于OMB在自身免疫性疾病发病机制中可能作用的文献。
我们使用包括口腔微生物组、自身免疫性疾病、生态失调和下一代测序等术语的检索策略，在PubMed、Medline、Research Gate和谷歌学术中检索英文发表的文章。
收集了大量文章，并用于描述OMB生态失调在干燥综合征、系统性红斑狼疮、类风湿性关节炎、白塞病、克罗恩病和银屑病发病机制中的可能影响。
这篇综述文章提请人们关注OMB与多种自身免疫性疾病触发之间的关系。尽管此前已对这一特定主题进行过综述，但在此，作者们综述了关于与OMB相关的所有疾病实体的最新文献，指出微生物组与性激素在自身免疫中的作用之间的相互作用，并讨论了针对系统性自身免疫性疾病的新颖且有前景的治疗方法。此外，还出现了OMB是否与口腔大疱性自身免疫性疾病相关的问题。
