Lima H G I F, Lopes I M S S, Oliveira A P B, Costa E V L, Aguiar L A A, Lindoso B P A, Silva M C O, Silva J E S, Nogueira R A
Laboratório de Biofísica Teórico-Experimental e Computacional, Departamento de Morfologia e Fisiologia Animal, Universidade Federal Rural de Pernambuco, Recife, PE, Brazil.
Laboratório de Biofísica Celular e Molecular - Universidade Federal de Pernambuco, Recife, PE, Brazil.
Biochem Biophys Rep. 2021 Apr 7;26:100992. doi: 10.1016/j.bbrep.2021.100992. eCollection 2021 Jul.
This study aimed to assess the effect of supplementation with omega-3 in Wistar rats exposed to ionizing radiation in a dose of 18 Gy on the cortical electrical activity, using mathematical methods such as the power spectrum (PS) and the detrended fluctuation analysis (DFA) in the evaluation of the electrocorticogram (ECoG) record. The PS analysis showed that in non-irradiated animals but supplemented with omega-3 there was a decrease in the power of the beta rhythm, while the DFA applied to different frequency ranges of the ECoG showed a significant increase in the long-range correlation only for the theta wave when compared with non-supplemented animals. In the evaluation of the radiation effect through the PS, an increase in the power of the theta rhythm was observed in both groups (non-supplemented and supplemented animals) only when they were evaluated one week after irradiation. The DFA method also showed difference in this wave. The PS and DFA methods applied to the ECoG record allowed a quantitative analysis of the cortical electrical activity in rats in response to the omega-3 effects, ionizing radiation, or both.
本研究旨在评估补充ω-3对接受18 Gy电离辐射的Wistar大鼠皮质电活动的影响，采用功率谱（PS）和去趋势波动分析（DFA）等数学方法评估脑电图（ECoG）记录。PS分析表明，在未受辐射但补充ω-3的动物中，β节律的功率降低，而应用于ECoG不同频率范围的DFA显示，与未补充的动物相比，仅θ波的长程相关性显著增加。在通过PS评估辐射效应时，仅在辐照一周后评估时，两组（未补充和补充的动物）的θ节律功率均增加。DFA方法在该波中也显示出差异。应用于ECoG记录的PS和DFA方法能够对大鼠皮质电活动对ω-3效应、电离辐射或两者的反应进行定量分析。
