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电离辐射在神经退行性疾病中的作用。

Role of Ionizing Radiation in Neurodegenerative Diseases.

作者信息

Sharma Neel K, Sharma Rupali, Mathur Deepali, Sharad Shashwat, Minhas Gillipsie, Bhatia Kulsajan, Anand Akshay, Ghosh Sanchita P

机构信息

Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.

Center for Neuroscience and Regenerative Medicine, Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.

出版信息

Front Aging Neurosci. 2018 May 14;10:134. doi: 10.3389/fnagi.2018.00134. eCollection 2018.

Abstract

Ionizing radiation (IR) from terrestrial sources is continually an unprotected peril to human beings. However, the medical radiation and global radiation background are main contributors to human exposure and causes of radiation sickness. At high-dose exposures acute radiation sickness occurs, whereas chronic effects may persist for a number of years. Radiation can increase many circulatory, age related and neurodegenerative diseases. Neurodegenerative diseases occur a long time after exposure to radiation, as demonstrated in atomic bomb survivors, and are still controversial. This review discuss the role of IR in neurodegenerative diseases and proposes an association between neurodegenerative diseases and exposure to IR.

摘要

来自地球天然源的电离辐射(IR)始终是人类面临的一种无防护危害。然而,医疗辐射和全球辐射本底是人类受照的主要来源以及辐射病的病因。在高剂量照射时会发生急性辐射病,而慢性影响可能会持续数年。辐射会增加许多循环系统疾病、与年龄相关的疾病以及神经退行性疾病。正如在原子弹爆炸幸存者中所显示的那样,神经退行性疾病在辐射暴露后很长时间才会出现,并且仍然存在争议。本综述讨论了电离辐射在神经退行性疾病中的作用,并提出了神经退行性疾病与电离辐射暴露之间的关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb71/5963202/1cc50ee4195b/fnagi-10-00134-g001.jpg

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