三名兄弟姐妹患血栓性血小板减少性紫癜和溶血性尿毒症综合征。
Thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome in three siblings.
作者信息
Elias M, Horowitz J, Tal I, Kohn D, Flatau E
机构信息
Department of Internal Medicine B, Central Emek Hospital, Afula, Israel.
出版信息
Arch Dis Child. 1988 Jun;63(6):644-6. doi: 10.1136/adc.63.6.644.
Abstract
Two brothers and one sister had three variants of thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome (the 'TTP-HUS' complex). The sister had a chronic fatal variant of thrombotic thrombocytopenic purpura with severe neurological manifestation. One brother had a chronic relapsing disease but the kidneys were not affected, and the other brother had haemolytic uraemic syndrome. This occurrence in one family supports the hypothesis that haemolytic uraemic syndrome and thrombotic thrombocytopenic purpura are actually two variants of the same disease.
摘要
两兄弟和一个姐妹患有血栓性血小板减少性紫癜和溶血性尿毒综合征（“TTP-HUS”综合征）的三种变体。该姐妹患有血栓性血小板减少性紫癜的慢性致命变体，并伴有严重的神经症状。一个兄弟患有慢性复发性疾病，但肾脏未受影响，另一个兄弟患有溶血性尿毒综合征。一个家族中出现这种情况支持了溶血性尿毒综合征和血栓性血小板减少性紫癜实际上是同一种疾病的两种变体这一假说。
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