Institute of Materials Research and Engineering, Agency for Science, Technology and Research, Singapore, 138634, Singapore.
Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Adv Healthc Mater. 2021 Sep;10(17):e2001916. doi: 10.1002/adhm.202001916. Epub 2021 Apr 25.
Owing to their excellent mechanical flexibility, mixed-conducting electrical property, and extraordinary chemical turnability, conjugated polymers have been demonstrated to be an ideal bioelectronic interface to deliver therapeutic effect in many different chronic diseases. This review article summarizes the latest advances in implantable electronics using conjugated polymers as electroactive materials and identifies remaining challenges and opportunities for developing electronic medicine. Examples of conjugated polymer-based bioelectronic devices are selectively reviewed in human clinical studies or animal studies with the potential for clinical adoption. The unique properties of conjugated polymers are highlighted and exemplified as potential solutions to address the specific challenges in electronic medicine.
由于其出色的机械柔韧性、混合传导的电学性能以及非凡的化学可转换性，共轭聚合物已被证明是一种理想的生物电子界面，可以在许多不同的慢性疾病中发挥治疗作用。本文总结了使用共轭聚合物作为电活性材料的可植入电子学的最新进展，并确定了开发电子医学的剩余挑战和机遇。本文选择性地回顾了基于共轭聚合物的生物电子设备在人体临床试验或具有临床应用潜力的动物研究中的实例。本文强调并举例说明了共轭聚合物的独特性质，这些性质可能是解决电子医学中特定挑战的潜在解决方案。
