State Key Laboratory of Cultivation and Protection for Non-Wood Forest Trees, Ministry of Education, Central South University of Forestry and Technology, Hunan 410004, China.
Key Laboratory of Insect Evolution and Pest Management for Higher Education in Hunan Province, Central South University of Forestry and Technology, Hunan 410004, China.
Plant Signal Behav. 2021 Jul 3;16(7):1917838. doi: 10.1080/15592324.2021.1917838. Epub 2021 Apr 25.
Rice tillering is an important characteristic that responds to both GA (gibberellin) and nitrogen-based fertilizers. How plants balance these two responses? A newly identified NGR5 (NITROGEN-MEDIATED TILLER GROWTH RESPONSE 5) protein reveals its important role in controlling the balance between GA-regulated dwarfism and nitrogen-regulated tillering. NGR5 directly interacts with PRC2 (Polycomb Repressive Complex 2) to form a repressive complex at the shoot branching inhibitory genes in nitrogen-dependent way, thereby repressing branching inhibitors and promoting tillering in response to nitrogen fertilizers. The GA receptor GID1 (GIBBERELLIN INSENSITIVE DWARF1) targets NGR5 for proteolysis by the 26S proteasome. The rice DELLA proteins of GA signaling way competitively inhibit GID1-NGR5 interaction, thereby protecting NGR5 from degradation and enhancing nitrogen-induced tiller number.
水稻分蘖是一种重要的特性，它对赤霉素（GA）和基于氮的肥料都有反应。植物如何平衡这两种反应？一种新发现的 NGR5（氮介导的分蘖生长响应 5）蛋白揭示了它在控制 GA 调节的矮化和氮调节的分蘖之间的平衡中的重要作用。NGR5 直接与 PRC2（多梳抑制复合物 2）相互作用，以氮依赖的方式在分枝抑制基因处形成抑制复合物，从而抑制分枝抑制剂并促进分蘖对氮肥的响应。GA 受体 GID1（赤霉素不敏感矮化 1）将 NGR5 作为 26S 蛋白酶体的靶标进行蛋白水解。GA 信号通路中的水稻 DELLA 蛋白竞争性抑制 GID1-NGR5 相互作用，从而保护 NGR5 免受降解，并增强氮诱导的分蘖数。
