von Glass W, Hauerstein T
ENT Department, University Hospital, Erlangen-Nuremberg, Federal Republic of Germany.
Arch Otorhinolaryngol. 1988;245(1):36-41. doi: 10.1007/BF00463546.
The wound healing of the mucous membrane of the nose was investigated in rabbits after irradiation with the argon laser. Immediately after application of the laser, a typical lesion showed a zonal appearance. Wound healing began after a delay of 6 days with the formation of granulation tissue. Re-epithelialization began from the margins of the wound and was characterized initially by metaplastic epithelium or squamous epithelium that was subsequently replaced by respiratory epithelium. In the subepithelial tissue plane, particularly following irradiation of the concha, a wider layer of connective tissue developed. The hyaline cartilage of the septum became necrotic over a large area which extended beyond the irradiated area, while the bone of the concha and the wall of the maxillary sinus was destroyed only at the site of the direct laser treatment.
用氩激光照射后，对家兔鼻黏膜的伤口愈合情况进行了研究。激光照射后立即出现典型的带状损伤。伤口愈合在延迟6天后开始，形成肉芽组织。重新上皮化从伤口边缘开始，最初的特征是化生上皮或鳞状上皮，随后被呼吸道上皮取代。在皮下组织平面，特别是在下鼻甲照射后，会形成更宽的结缔组织层。鼻中隔的透明软骨大面积坏死，坏死范围超出照射区域，而下鼻甲和上颌窦壁的骨组织仅在直接激光治疗部位被破坏。
