Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea.
College of Chemistry, State Key Laboratory of Photocatalysis for Energy and the Environment, Fujian Provincial Key Laboratory for Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou 350108, China.
ACS Appl Mater Interfaces. 2021 May 5;13(17):19543-19571. doi: 10.1021/acsami.1c02019. Epub 2021 Apr 26.
Subcellular organelles are the cornerstones of cells, and destroying them will cause cell dysfunction and even death. Therefore, realizing precise organelle targeting of photosensitizers (PSs) can help reduce PS dosage, minimize side effects, avoid drug resistance, and enhance therapeutic efficacy in photodynamic therapy (PDT). Organelle-targeted PSs provide a new paradigm for the construction of the next generation of PSs and may provide implementable strategies for future precision medicine. In this Review, the recent targeting strategies of different organelles and the corresponding design principles of molecular and nanostructured PSs are summarized and discussed. The current challenges and opportunities in organelle-targeted PDT are also presented.
亚细胞细胞器是细胞的基石，破坏它们会导致细胞功能障碍甚至死亡。因此，实现光敏剂（PSs）的精确细胞器靶向可以帮助减少 PS 用量、最小化副作用、避免耐药性，并提高光动力疗法（PDT）的治疗效果。细胞器靶向 PS 为构建下一代 PS 提供了新的范例，也可能为未来的精准医学提供可行的策略。在这篇综述中，总结和讨论了不同细胞器的靶向策略以及分子和纳米结构 PS 的相应设计原则。还介绍了细胞器靶向 PDT 目前面临的挑战和机遇。
