Hyman F C, Collins W E, Taylor H L, Domino E F, Nagel R J
Aviation Research Laboratory, University of Illinois, Savoy.
Aviat Space Environ Med. 1988 Jun;59(6):533-9.
Two different combinations of antiemetic drugs were evaluated using a digital flight simulator. Drug treatments consisted of a lactose placebo, a combination of thiethylperazine (10 mg) and cimetidine (300 mg), and a combination which added promethazine (25 mg) to the two-drug combination. The performance effects of these combinations were evaluated on both a dual task (instrument flight task with the Sternberg Memory Scanning task) and a single task condition (Sternberg task only) for 3 h post drug ingestion. Analysis indicated a significant treatment effect on three of the six flight performance variables and that the three-drug combination, containing promethazine, was primarily responsible for the decrease in performance. Implications for operation in a radiation environment are that thiethylperazine and cimetidine will not cause significant performance decrements, but the addition of promethazine to those two drugs will significantly impair performance. The Sternberg task was sensitive to changes in workload.
使用数字飞行模拟器评估了两种不同的止吐药物组合。药物治疗包括乳糖安慰剂、硫乙拉嗪（10毫克）和西咪替丁（300毫克）的组合，以及在两药组合中添加异丙嗪（25毫克）的组合。在服药后3小时内，在双重任务（仪器飞行任务与斯特恩伯格记忆扫描任务）和单一任务条件（仅斯特恩伯格任务）下评估了这些组合的性能影响。分析表明，对六个飞行性能变量中的三个有显著的治疗效果，并且含有异丙嗪的三药组合是性能下降的主要原因。在辐射环境中操作的影响是，硫乙拉嗪和西咪替丁不会导致显著的性能下降，但在这两种药物中添加异丙嗪会显著损害性能。斯特恩伯格任务对工作量的变化很敏感。
