Section of Rheumatology, Boston University School of Medicine, Boston, MA, USA; University of Manchester and the NIHR, Manchester Musculoskeletal Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
Section of Rheumatology, Boston University School of Medicine, Boston, MA, USA.
Osteoarthritis Cartilage. 2021 Dec;29(12):1666-1672. doi: 10.1016/j.joca.2021.03.017. Epub 2021 Apr 24.
To determine how many persons with knee pain have subsequent pain resolution and what factors are associated with resolution, focusing especially on types of physical activity.
Using data from MOST, an NIH funded longitudinal cohort study of persons with or at risk of knee osteoarthritis, we studied participants who at baseline reported knee pain on most days at both a telephone interview and clinic visit. We defined pain resolution if at 30 and 60 month exams, they reported no knee pain on most days and compared these participants to those who reported persistent pain later. In logistic regression analyses, we examined the association of baseline risk factors including demographic factors, BMI, depressive symptoms, isokinetic quadriceps strength and both overall physical activity (using the PASE survey) and specific activities including walking, gardening, and different intensities of recreational activities with pain resolution.
Of 1,304 participants with knee pain on most days at baseline, 265 (20.3%) reported no knee pain at 30 and 60 months. Lower BMI and stronger quadriceps were associated with higher odds of pain resolution while overall physical activity was not. Of activities, walking decreased the odds of pain resolution (adjOR = 0.86 (95% CI 0.76, 0.98)), but gardening (adjOR = 1.59 (1.16, 2.18)) and moderate intensity recreational activities ((adjOR = 1.24 (1.05, 1.46)) increased it.
Pain resolution is common in those with knee pain. Factors increasing the odds of pain resolution include lower BMI, greater quadriceps strength and gardening and moderately intensive recreational activities.
确定有膝关节疼痛的患者中有多少人随后疼痛缓解，以及哪些因素与缓解相关，尤其关注身体活动的类型。
利用美国国立卫生研究院（NIH）资助的膝关节骨关节炎患者或高危人群的纵向队列研究（MOST）的数据，我们研究了在基线时，电话访谈和临床就诊时均报告多数日子有膝关节疼痛的参与者。如果在 30 个月和 60 个月的检查时，他们报告多数日子无膝关节疼痛，则定义为疼痛缓解，并将这些参与者与后来报告持续疼痛的参与者进行比较。在逻辑回归分析中，我们检查了基线风险因素（包括人口统计学因素、BMI、抑郁症状、等速股四头肌力量以及总体身体活动（使用 PASE 调查）和特定活动，包括步行、园艺和不同强度的娱乐活动）与疼痛缓解的关联。
在基线时有多数日子膝关节疼痛的 1304 名参与者中，有 265 名（20.3%）在 30 个月和 60 个月时报告无膝关节疼痛。较低的 BMI 和较强的股四头肌与疼痛缓解的可能性更高相关，而总体身体活动则不然。在活动方面，步行降低了疼痛缓解的可能性（调整后的 OR=0.86（95%CI 0.76, 0.98）），但园艺（调整后的 OR=1.59（1.16, 2.18））和中等强度的娱乐活动（调整后的 OR=1.24（1.05, 1.46））则增加了疼痛缓解的可能性。
膝关节疼痛患者中疼痛缓解较为常见。增加疼痛缓解可能性的因素包括较低的 BMI、较强的股四头肌力量以及园艺和中等强度的娱乐活动。
