Fuwai Hospital, Peking Union Medical College, and Chinese Academy of Medical Sciences, Beijing, China.
Yantai Center for Disease Control and Prevention, Yantai, Shandong Province, China.
Arthritis Care Res (Hoboken). 2022 Jul;74(7):1163-1171. doi: 10.1002/acr.24554. Epub 2022 Apr 13.
To determine whether the amount of physical activity (PA) is a determinant of joint space narrowing (JSN) worsening over 48 months in participants with knee osteoarthritis.
Data were obtained from the Osteoarthritis Initiative. PA, measured using the Physical Activity Scale for the Elderly (PASE), was defined as the mean value of the annual measurements conducted prior to development of worsening JSN. Worsening JSN was defined as at least a partial grade increase in the Osteoarthritis Research Society International JSN score over 48 months, in comparison with baseline. Restricted cubic spline function was used to group participants based on the linear association between PA and JSN worsening. A pooled logistic regression model was used to evaluate the association between PA and JSN worsening adjusted for confounders.
A total of 2,167 participants were included. In total, 625 participants (28.8%) had JSN worsening over 48 months. Compared with a PASE score of 141-180, PASE scores of 101-140 and >220 were associated with an increased risk of JSN worsening in men, with odds ratios (ORs) of 1.73 (95% confidence interval [95% CI] 1.07-2.81) and 1.83 (95% CI 1.14-2.93), respectively. Similarly, in participants with Kellgren/Lawrence (K/L) grade 2, compared with a PASE score of 141-180, PASE scores of ≤100 and >220 were associated with increased risks of JSN worsening, with an OR of 1.69 (95% CI 1.13-2.54) and 1.64 (95% CI 1.05-2.56), respectively.
Compared to moderate PA, higher or lower amounts of PA are associated with an elevated risk for JSN worsening in men and in participants with K/L grade 2 knees.
确定身体活动（PA）量是否是膝关节骨关节炎患者 48 个月内关节间隙狭窄（JSN）恶化的决定因素。
数据来自骨关节炎倡议。使用老年人体力活动量表（PASE）测量 PA，定义为在 JSN 恶化前进行的年度测量的平均值。JSN 恶化定义为与基线相比，48 个月内至少出现 OARSI JSN 评分的部分等级增加。使用受限立方样条函数根据 PA 与 JSN 恶化之间的线性关联对参与者进行分组。使用汇总逻辑回归模型调整混杂因素后评估 PA 与 JSN 恶化之间的关联。
共纳入 2167 名参与者。共有 625 名参与者（28.8%）在 48 个月内出现 JSN 恶化。与 PASE 评分 141-180 相比，PASE 评分 101-140 和>220 与男性 JSN 恶化风险增加相关，优势比（OR）分别为 1.73（95%置信区间[95%CI] 1.07-2.81）和 1.83（95%CI 1.14-2.93）。同样，在 K/L 分级 2 的参与者中，与 PASE 评分 141-180 相比，PASE 评分≤100 和>220 与 JSN 恶化风险增加相关，OR 分别为 1.69（95%CI 1.13-2.54）和 1.64（95%CI 1.05-2.56）。
与适度 PA 相比，男性和 K/L 分级 2 膝关节中较高或较低的 PA 量与 JSN 恶化风险增加相关。
