Brigham and Women's Hospital, Center for Weight Management and Wellness, Section of Endocrinology, Diabetes and Hypertension, Harvard Medical School, Boston, Massachusetts.
Brigham and Women's Hospital, Center for Weight Management and Wellness, Section of Endocrinology, Diabetes and Hypertension, Harvard Medical School, Boston, Massachusetts.
Endocr Pract. 2021 Jun;27(6):626-635. doi: 10.1016/j.eprac.2021.04.001. Epub 2021 Apr 24.
Obesity is a chronic illness that requires a multifaceted personalized treatment approach.
METHODS & FINDINGS: Using current guidelines and recent studies in weight management, this article reviews the multiple components of weight management: lifestyle intervention (dietary intervention, physical activity, and behavioral interventions), pharmacotherapy, endoscopic procedures, and surgical procedures. This review briefly discusses specific diets and dietary strategies, compensatory mechanisms acting against weight loss, recent changes to Food and Drug Administration approved antiobesity medications, and technological advances in weight management delivery.
Current literature is lacking large studies on the safety and efficacy of combination therapies involving pharmacotherapy plus 1 or more procedures.
肥胖是一种慢性病，需要采取多方面的个性化治疗方法。
本文参考当前的指南和体重管理领域的最新研究，综述了体重管理的多个组成部分：生活方式干预（饮食干预、身体活动和行为干预）、药物治疗、内镜程序和手术程序。本文简要讨论了特定的饮食和饮食策略、对抗减肥的补偿机制、美国食品和药物管理局批准的抗肥胖药物的最新变化以及体重管理方法的技术进步。
目前缺乏关于药物治疗联合 1 种或多种程序的组合疗法的安全性和有效性的大型研究。
