Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA.
Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC, USA.
J Environ Sci Health C Toxicol Carcinog. 2021;39(2):219-233. doi: 10.1080/26896583.2020.1865027.
Astronauts embarking on deep space missions are at high risk of long-term exposure to low doses of high linear energy transfer (LET) radiation, which can contribute to the development of cancer and multiple degenerative diseases. However, long term effects of exposure to low doses of high LET radiation in plasma metabolite profiles have not been elucidated. We utilized an untargeted metabolomics and lipidomics approach to analyze plasma obtained from adult male Long Evans rats to determine the longitudinal effects of low-dose proton and low-dose oxygen ion whole-body irradiation on metabolic pathways. Our findings reveal that radiation exposure induced modest changes in the metabolic profiles in plasma, 7 months after exposure. Furthermore, we identified some common metabolite dysregulations between protons and oxygen ions, which may indicate a similar mechanism of action for both radiation types.
宇航员在执行深空任务时，长期暴露于低剂量的高线性能量转移（LET）辐射下的风险很高，这可能导致癌症和多种退行性疾病的发生。然而，低剂量高 LET 辐射在等离子体代谢物谱中的长期影响尚未阐明。我们利用非靶向代谢组学和脂质组学方法分析成年雄性 Long Evans 大鼠的血浆，以确定低剂量质子和低剂量氧离子全身照射对代谢途径的纵向影响。我们的研究结果表明，辐射暴露在暴露后 7 个月会导致血浆代谢谱发生适度变化。此外，我们还发现质子和氧离子之间存在一些共同的代谢物失调，这可能表明这两种辐射类型具有相似的作用机制。
