A review of biosensor technology and algorithms for glucose monitoring.

Diabetes mellitus (DM) has become a serious illness in the whole world. Until now, there is no effective cure for patients with DM. It is well known that the glucose level is one key factor to determine the progress of DM. It is also an important reference to carry out the accurate and timely treatment for patients with DM. In this article, the related biosensors technology that can be utilized to identify and predict glucose level are reviewed in detail, including the algorithms that can help to achieve numerical value of glucose level. Firstly, the biosensor technology based on the physiological fluids are illustrated, including blood, sweat, interstitial fluid, ocular fluid, and other available fluids. Secondly, the algorithms for achieving numerical value of glucose level are investigated, including the physiological model-based method and the machine learning-based method. Finally, the future development trend and challenges of glucose level monitoring are given and the conclusions are drawn.