Caygill C, Hill M, Kirkham J, Northfield T C
Norman Tanner Gastroenterology Unit, St James Hospital, Balham, London, UK.
Br J Cancer. 1988 Apr;57(4):434-6. doi: 10.1038/bjc.1988.98.
Analysis of 4,466 peptic ulcer patients, who had undergone gastric surgery at least 25 years previously, showed no change in risk from biliary tract cancer within the first 20 years, but a 9.4 fold (P less than 0.001) excess risk thereafter. The increased risk was 15.8 fold (P less than 0.001) 20 years after operation for gastric ulcer patients and 5.1 fold (NS) in duodenal ulcer patients. When the risk was analysed by subsite it was found that there was no increased risk at any time after operation for cancer of the bile duct, and that all of the excess risk 20 or more years after operation (14.7 fold; P less than 0.001) was for cancer of the gallbladder.
对4466例至少在25年前接受过胃部手术的消化性溃疡患者进行分析，结果显示，在最初20年内，患胆道癌的风险没有变化，但此后风险增加了9.4倍（P<0.001）。胃溃疡患者术后20年风险增加了15.8倍（P<0.001），十二指肠溃疡患者增加了5.1倍（无统计学意义）。按亚部位分析风险时发现，术后任何时候胆管癌风险均未增加，术后20年及以上的所有额外风险（14.7倍；P<0.001）均为胆囊癌。
