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人脂肪间充质干细胞来源的细胞外囊泡：常见 cargos 的综述。

Extracellular Vesicles from Human Adipose-Derived Mesenchymal Stem Cells: A Review of Common Cargos.

机构信息

Ocular Surface Group, Instituto de Oftalmobiología Aplicada (IOBA), Universidad de Valladolid, Valladolid, Spain.

Centro de Investigación Biomédica en Red en el área temática de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Valladolid, Spain.

出版信息

Stem Cell Rev Rep. 2022 Mar;18(3):854-901. doi: 10.1007/s12015-021-10155-5. Epub 2021 Apr 26.

DOI:10.1007/s12015-021-10155-5
PMID:33904115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8942954/
Abstract

In recent years, the interest in adipose tissue mesenchymal cell-derived extracellular vesicles (AT-MSC-EVs) has increasingly grown. Numerous articles support the potential of human AT-MSC-EVs as a new therapeutic option for treatment of diverse diseases in the musculoskeletal and cardiovascular systems, kidney, skin, and immune system, among others. This approach makes use of the molecules transported inside of EVs, which play an important role in cell communication and in transmission of macromolecules. However, to our knowledge, there is no database where essential information about AT-MSC-EVs cargo molecules is gathered for easy reference. The aim of this study is to describe the different molecules reported so far in AT-MSC- EVs, their main molecular functions, and biological processes in which they are involved. Recently, the presence of 591 proteins and 604 microRNAs (miRNAs) has been described in human AT-MSC-EVs. The main molecular function enabled by both proteins and miRNAs present in human AT-MSC-EVs is the binding function. Signal transduction and gene silencing are the biological processes in which a greater number of proteins and miRNAs from human AT-MSC-EVs are involved, respectively. In this review we highlight the therapeutics effects of AT-MSC-EVs related with their participation in relevant biological processes including inflammation, angiogenesis, cell proliferation, apoptosis and migration, among others.

摘要

近年来，人们对脂肪组织间充质细胞衍生的细胞外囊泡（AT-MSC-EVs）的兴趣日益增长。大量的文章支持人类 AT-MSC-EVs 作为一种新的治疗选择，可用于治疗肌肉骨骼和心血管系统、肾脏、皮肤和免疫系统等多种疾病。这种方法利用了 EVs 内部运输的分子，这些分子在细胞通讯和大分子传递中发挥着重要作用。然而，据我们所知，目前还没有一个数据库可以方便地收集关于 AT-MSC-EVs 货物分子的重要信息。本研究的目的是描述迄今为止在 AT-MSC-EVs 中报道的不同分子，以及它们的主要分子功能和参与的生物学过程。最近，已经在人脂肪间充质细胞衍生的细胞外囊泡中描述了 591 种蛋白质和 604 种 microRNAs（miRNAs）。在人脂肪间充质细胞衍生的细胞外囊泡中存在的蛋白质和 miRNAs 所具有的主要分子功能是结合功能。信号转导和基因沉默是涉及人脂肪间充质细胞衍生的细胞外囊泡中更多蛋白质和 miRNAs 的生物学过程。在这篇综述中，我们强调了 AT-MSC-EVs 的治疗效果，这与其参与相关生物学过程有关，包括炎症、血管生成、细胞增殖、凋亡和迁移等。

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