南亚成年人血脂异常的患病率及血脂异常相关因素：南亚心血管代谢风险降低中心队列研究。

Prevalence of dyslipidaemia and factors associated with dyslipidaemia among South Asian adults: The Center for Cardiometabolic Risk Reduction in South Asia Cohort Study.

机构信息

Aga Khan University (AKU), Karachi, Pakistan.

Public Health Foundation of India (PHFI), Gurugram, Haryana, India and Centre for Chronic Disease Control, New Delhi, India.

出版信息

Natl Med J India. 2020 May-Jun;33(3):137-145. doi: 10.4103/0970-258X.314005.

DOI:10.4103/0970-258X.314005

PMID:33904416

Abstract

BACKGROUND

. The pattern of dyslipidaemia in South Asia is believed to be different from that in other parts of the world. Nonetheless, limited population-based data are available from the region. We assessed the prevalence, types of, and factors associated with dyslipidaemia among South Asians.

METHODS

. We used baseline data (2010-11) of the Center for Cardiometabolic Risk Reduction in South Asia (CARRS) cohort of 16 287 representative urban adults aged ≥20 years from Chennai and Delhi in India and Karachi in Pakistan. Total cholesterol (TC) was measured by the enzymatic-cholesterol oxidase peroxidase method, high-density lipoprotein-cholesterol (HDL-C) by the direct homogeneous method and triglycerides (TG) by enzymatic methods. Low-density lipoprotein-cholesterol (LDL-C) was calculated using Friedewald's formula. We defined high TC ≥200 mg/dl or on medication; hypertriglyceridaemia ≥150 mg/dl, high LDL-C ≥130 mg/dl or on medication and low HDL-C <40 mg/dl for males, <50 mg/dl for females. Multivariate logistic regression was carried out to assess the factors associated with dyslipidaemia.

RESULTS

. The prevalence of any dyslipidaemia was 76.4%, 64.3% and 68.5% among males and 89.3%, 74.4% and 79.4% among females in Chennai, Delhi and Karachi, respectively. The prevalence of elevated TC was higher in Chennai compared to Delhi and Karachi (31.3%, 28.8% and 22.9%, respectively); males had a significantly greater prevalence of high TG, whereas females had a greater prevalence of low HDL-C in all the three cities. The most common lipid abnormality in all three cities was low HDL-C, which was seen in 67.1%, 49.7% and 61.3% in Chennai, Delhi and Karachi, respectively. Only 2% of the participants were on lipid-lowering drugs. Adjusted for other factors, dyslipidaemia was positively associated with age, female sex, obesity, hypertension, diabetes and tobacco use.

DISCUSSION

. Overall, almost seven in ten adults in urban South Asia have some form of dyslipidaemia, and the predominant subtypes were low HDL-C and high TG.

摘要

背景

南亚的血脂异常模式被认为与世界其他地区不同。尽管如此，该地区的人口基础数据有限。我们评估了南亚人群中血脂异常的流行率、类型和相关因素。

方法

我们使用了来自印度钦奈和德里以及巴基斯坦卡拉奇的中心心血管代谢风险降低南亚（CARRS）队列的 16287 名代表性城市成年居民的基线数据（2010-11 年）。总胆固醇（TC）采用酶胆固醇氧化酶过氧化物酶法测定，高密度脂蛋白胆固醇（HDL-C）采用直接均相法测定，甘油三酯（TG）采用酶法测定。低密度脂蛋白胆固醇（LDL-C）采用弗里德瓦尔德公式计算。我们将高 TC 定义为≥200mg/dl 或正在服用药物；高甘油三酯血症定义为≥150mg/dl，高 LDL-C 定义为≥130mg/dl 或正在服用药物，低 HDL-C 定义为男性<40mg/dl，女性<50mg/dl。采用多变量逻辑回归评估与血脂异常相关的因素。

结果

男性在钦奈、德里和卡拉奇的血脂异常总患病率分别为 76.4%、64.3%和 68.5%，女性分别为 89.3%、74.4%和 79.4%。与德里和卡拉奇相比，钦奈的 TC 升高患病率更高（分别为 31.3%、28.8%和 22.9%）；男性高 TG 患病率显著更高，而女性在所有三个城市中低 HDL-C 患病率更高。在所有三个城市中最常见的脂质异常是低 HDL-C，在钦奈、德里和卡拉奇的患病率分别为 67.1%、49.7%和 61.3%。只有 2%的参与者正在服用降脂药物。调整其他因素后，血脂异常与年龄、女性、肥胖、高血压、糖尿病和吸烟呈正相关。