Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, China.
Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Wuhan, China.
Eur J Pharmacol. 2021 Jul 5;902:174120. doi: 10.1016/j.ejphar.2021.174120. Epub 2021 Apr 24.
Atherosclerosis can cause severe cardiovascular diseases, which is the most common cause of death in the world. It's of great significance to study the prevention and treatment of atherosclerosis. Selenium nanoparticles (SeNPs) has drawn more and more attention due to high biological activity, high bioavailability, strong antioxidant capacity and low toxicity, exhibiting great potential in biomedical application. Thus, this study aimed at explore the anti-atherosclerotic effect of two kinds of SeNPs, bovine serum albumin (BSA) surface-decorated SeNPs and chitosan (CS) surface-decorated SeNPs (CS-SeNPs), in apolipoprotein E deficient (ApoE) mice fed with a high-cholesterol and high-fat diet, and the possible mechanisms. The results demonstrated that both BSA-SeNPs (25, 50 and 100 μg Se/kg body weight/day) and CS-SeNPs (50 μg Se/kg body weight/day) could reduce atherosclerotic lesions in ApoE mice after oral administration for 12 weeks. And these effects might mainly attributed to the ability of BSA-SeNPs and CS-SeNPs to inhibit hyperlipidemia by suppressing hepatic cholesterol and fatty acid metabolism, and alleviate oxidative stress by enhancing antioxidant activity. Moreover, the benefits of BSA-SeNPs were dose-dependent and the medium dose of BSA-SeNPs (50 μg Se/kg body weight/day) was optimal. Generally, BSA-SeNPs with mean size 38.5 nm and negative surface charge showed better anti-atherosclerotic effect than CS-SeNPs with mean size 65.8 nm and positive surface charge. These results suggested that SeNPs could significantly alleviate the formation of atherosclerosis in ApoE mice, possibly by inhibiting hyperlipidemia and oxidative stress, exhibiting a potential to serve as an anti-atherosclerotic agent.
动脉粥样硬化可导致严重的心血管疾病，是世界上最常见的死亡原因。研究动脉粥样硬化的防治具有重要意义。硒纳米粒子（SeNPs）由于具有高生物活性、高生物利用度、强抗氧化能力和低毒性而受到越来越多的关注，在生物医学应用中显示出巨大的潜力。因此，本研究旨在探讨两种硒纳米粒子，即牛血清白蛋白（BSA）表面修饰的硒纳米粒子（BSA-SeNPs）和壳聚糖（CS）表面修饰的硒纳米粒子（CS-SeNPs），对高脂高胆固醇饮食喂养的载脂蛋白 E 缺陷（ApoE）小鼠的抗动脉粥样硬化作用及其可能的机制。结果表明，BSA-SeNPs（25、50 和 100μg Se/kg 体重/天）和 CS-SeNPs（50μg Se/kg 体重/天）经口服给药 12 周后均可减少 ApoE 小鼠的动脉粥样硬化病变。这些作用可能主要归因于 BSA-SeNPs 和 CS-SeNPs 通过抑制肝脏胆固醇和脂肪酸代谢来抑制高脂血症，以及通过增强抗氧化活性来减轻氧化应激。此外，BSA-SeNPs 的益处呈剂量依赖性，其中中剂量 BSA-SeNPs（50μg Se/kg 体重/天）效果最佳。一般来说，平均粒径为 38.5nm、带负电荷的 BSA-SeNPs 比平均粒径为 65.8nm、带正电荷的 CS-SeNPs 具有更好的抗动脉粥样硬化作用。这些结果表明，SeNPs 可显著减轻 ApoE 小鼠动脉粥样硬化的形成，可能通过抑制高脂血症和氧化应激来发挥作用，有望成为一种抗动脉粥样硬化药物。
