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[新冠病毒疫苗接种:临床试验后的现实情况]

[COVID-19 vaccination: the reality after clinical trials].

作者信息

Ruiz-Galiana J, Cantón R, De Lucas Ramos P, García-Botella A, García-Lledó A, Gómez-Pavón J, González Del Castillo J, Hernández-Sampelayo T, Martín-Delgado M C, Martín Sánchez F J, Martínez-Sellés M, Molero García J M, Moreno Guillén S, Rodríguez-Artalejo F J, Bouza E

机构信息

Servicio de Microbiología Clínica y Enfermedades Infecciosas del Hospital General Universitario Gregorio Marañón, Universidad Complutense. CIBERES. Ciber de Enfermedades Respiratorias. Madrid, Spain.

出版信息

Rev Esp Quimioter. 2021 Oct;34(5):408-418. doi: 10.37201/req/035.2021. Epub 2021 Apr 28.

DOI:10.37201/req/035.2021
PMID:33906339
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8638833/
Abstract

After the start of vaccination against SARS-CoV-2, enough clinical experience is already accumulating, in the real world and outside clinical trials, to resolve some of the questions that are still pending about this problem. The Scientific Committee on COVID-19 of the Madrid College of Physicians has discussed and reviewed some of these issues with a multidisciplinary approach. The following document is an attempt to answer some of these questions with the information available so far. This document is structured in questions on different aspects of the indications, efficacy and tolerance of anti-COVID-19 vaccination.

摘要

在开始接种针对严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的疫苗后,在现实世界和临床试验之外已经积累了足够的临床经验,以解决有关该问题仍悬而未决的一些问题。马德里医师学院的COVID-19科学委员会已采用多学科方法讨论并审查了其中一些问题。以下文件试图利用目前可用的信息回答其中一些问题。本文档围绕抗COVID-19疫苗接种的适应症、疗效和耐受性等不同方面的问题展开。

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本文引用的文献

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The vaccine against COVID-19 and institutional trust.针对 COVID-19 的疫苗和机构信任。
Enferm Infecc Microbiol Clin (Engl Ed). 2021 Dec;39(10):510-515. doi: 10.1016/j.eimce.2021.09.001. Epub 2021 Sep 10.
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Covid-19: US suspends Johnson and Johnson vaccine rollout over blood clots.新冠疫情:美国因血栓问题暂停强生疫苗接种计划。
BMJ. 2021 Apr 13;373:n970. doi: 10.1136/bmj.n970.
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Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination.接种 ChAdOx1 nCov-19 疫苗后发生血栓性血小板减少症。
N Engl J Med. 2021 Jun 3;384(22):2092-2101. doi: 10.1056/NEJMoa2104840. Epub 2021 Apr 9.
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Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination.ChAdOx1新冠疫苗接种后的血栓形成和血小板减少症
N Engl J Med. 2021 Jun 3;384(22):2124-2130. doi: 10.1056/NEJMoa2104882. Epub 2021 Apr 9.
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Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA-1273 COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential and Frontline Workers - Eight U.S. Locations, December 2020-March 2021.BNT162b2 疫苗和 mRNA-1273 新冠疫苗在预防医护人员、第一响应者和其他必要及一线工作人员感染 SARS-CoV-2 中的疫苗有效性的临时估计-2020 年 12 月至 2021 年 3 月美国 8 个地点。
MMWR Morb Mortal Wkly Rep. 2021 Apr 2;70(13):495-500. doi: 10.15585/mmwr.mm7013e3.
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Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine.接种 BNT162b2 疫苗后 SARS-CoV-2 病毒载量下降的初步报告。
Nat Med. 2021 May;27(5):790-792. doi: 10.1038/s41591-021-01316-7. Epub 2021 Mar 29.
7
Immunogenicity of the Ad26.COV2.S Vaccine for COVID-19.COVID-19 用 Ad26.COV2.S 疫苗的免疫原性。
JAMA. 2021 Apr 20;325(15):1535-1544. doi: 10.1001/jama.2021.3645.
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Safety of New mRNA Vaccines Against COVID-19 in Severely Allergic Patients.新型mRNA新冠疫苗在重度过敏患者中的安全性
J Investig Allergol Clin Immunol. 2021 Apr 20;31(2):180-181. doi: 10.18176/jiaci.0683. Epub 2021 Mar 2.
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Effect of previous SARS-CoV-2 infection on humoral and T-cell responses to single-dose BNT162b2 vaccine.既往感染严重急性呼吸综合征冠状病毒2(SARS-CoV-2)对单剂量BNT162b2疫苗体液和T细胞反应的影响
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