Department of Human Anatomy, Xuzhou Medical University, Xuzhou, China.
Jiangsu Medical Engineering Research Center of Gene Detection and Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, China.
J Biomater Appl. 2021 Oct;36(4):714-721. doi: 10.1177/08853282211012870. Epub 2021 Apr 28.
Faster recovery and fewer scars are ideal wound healing. We have demonstrated that the cannabinoid receptor 2 (CB) agonist Gp1a is beneficial to skin wound healing, which inhibits inflammation and fibrogenesis while promoting re-epithelialization. However, the systemic administration is imprecise and overqualified for a local skin wound. Herein, we prepared Gp1a-gel using triglycerol monostearate (Tm) hydrogel and detected whether the Gp1a-gel worked effectively on mouse skin excision wounds. The results showed that Gp1a-gel might sustainably increase the CB for at least 8 days. It decreased inflammation and fibrogenesis while promoting wound enclosure and re-epithelialization. These results suggested Gp1a-gel may utilize as a potential formulation strategy to treat the skin wound.
更快的恢复和更少的疤痕是理想的伤口愈合。我们已经证明，大麻素受体 2（CB）激动剂 Gp1a 有利于皮肤伤口愈合，它抑制炎症和纤维化，同时促进再上皮化。然而，全身给药对于局部皮肤伤口来说不够精确和过度。在此，我们使用三硬脂酸甘油酯（Tm）水凝胶制备了 Gp1a-凝胶，并检测了 Gp1a-凝胶是否能有效作用于小鼠皮肤切除伤口。结果表明，Gp1a-凝胶可能至少持续 8 天增加 CB。它减少炎症和纤维化，同时促进伤口闭合和再上皮化。这些结果表明 Gp1a-凝胶可作为一种潜在的制剂策略用于治疗皮肤伤口。
