Parikh Aniruddha C, Jeffery Christopher S, Sandhu Zainab, Brownlee Benjamin P, Queimado Lurdes, Mims Mark M
Departments of Otolaryngology Head and Neck Surgery The University of Oklahoma Health Sciences Center Oklahoma City Oklahoma USA.
Departments of General Surgery The University of Oklahoma Health Sciences Center Oklahoma City Oklahoma USA.
Health Sci Rep. 2024 Feb 25;7(2):e1908. doi: 10.1002/hsr2.1908. eCollection 2024 Feb.
Cannabis and its various derivatives are commonly used for both recreational and medicinal purposes. Cannabinoids have been shown to have anti-inflammatory properties. Inflammation is an important component of wound healing and the effect of cannabinoids on wound healing has become a recent topic of investigation. The objective of this article is to perform a comprehensive review of the literature to summarize the effects of cannabinoids on wound healing of the skin and to guide future avenues of research.
A comprehensive literature review was performed to evaluate the effects of cannabinoids on cutaneous wound healing.
Cannabinoids appear to improve skin wound healing through a variety of mechanisms. This is supported through a variety of in vitro and animal studies. Animal studies suggest application of cannabinoids may improve the healing of postsurgical and chronic wounds. There are few human studies which evaluate the effects of cannabinoids on wound healing and many of these are case series and observational studies. They do suggest cannabinoids may have some benefit. However, definitive conclusions cannot be drawn from them.
While further human studies are needed, topical application of cannabinoids may be a potential therapeutic option for postsurgical and chronic wounds.
大麻及其各种衍生物常用于娱乐和医疗目的。大麻素已被证明具有抗炎特性。炎症是伤口愈合的重要组成部分，大麻素对伤口愈合的影响已成为近期的研究课题。本文的目的是对文献进行全面综述，总结大麻素对皮肤伤口愈合的影响，并指导未来的研究方向。
进行了全面的文献综述，以评估大麻素对皮肤伤口愈合的影响。
大麻素似乎通过多种机制促进皮肤伤口愈合。这得到了各种体外和动物研究的支持。动物研究表明，应用大麻素可能改善术后伤口和慢性伤口的愈合。很少有人类研究评估大麻素对伤口愈合的影响，其中许多是病例系列和观察性研究。这些研究确实表明大麻素可能有一些益处。然而，无法从中得出明确的结论。
虽然需要进一步的人体研究，但局部应用大麻素可能是术后伤口和慢性伤口的一种潜在治疗选择。
