Gopakumar Nikita, Ali Abdulla M, Oudda Sumayah, Singam Amarnath, Park Seungman
Department of Mechanical Engineering, University of Nevada, Las Vegas, Las Vegas, USA.
Department of Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Adv Exp Med Biol. 2025;1474:35-51. doi: 10.1007/5584_2024_817.
Advancements in tissue engineering enable the fabrication of complex and functional tissues or organs. In particular, bioprinting enables controlled and accurate deposition of cells, biomaterials, and growth factors to create complex 3D skin constructs specific to a particular individual. Despite these advancements, challenges such as vascularization, long-term stability, and regulatory considerations hinder the clinical translation of bioprinted skin constructs. This chapter focuses on such approaches using advanced biomaterials and bioprinting techniques to overcome the current barriers in wound-healing studies. Moreover, it addresses current obstacles in wound-healing studies, highlighting the need for continued research and innovation to overcome these barriers and facilitate the practical utilization of bioprinted skin constructs in clinical settings.
组织工程学的进展使得制造复杂且具有功能的组织或器官成为可能。特别是，生物打印能够实现细胞、生物材料和生长因子的可控且精确沉积，以创建针对特定个体的复杂三维皮肤构建体。尽管有这些进展，但诸如血管化、长期稳定性以及监管考量等挑战阻碍了生物打印皮肤构建体的临床转化。本章重点介绍使用先进生物材料和生物打印技术的此类方法，以克服伤口愈合研究中的当前障碍。此外，它还阐述了伤口愈合研究中的当前障碍，强调需要持续研究和创新以克服这些障碍，并促进生物打印皮肤构建体在临床环境中的实际应用。
