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食管癌伴孤立性髌骨转移:一例罕见病例报告

Oesophageal carcinoma with solitary patellar metastasis: a rare case report.

作者信息

Zhao Yi, Zhang Qianqian, Feng Helin, Zhu Xiyan

机构信息

Department of Orthopedics, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, P. R. China.

Department of Gynecology, Hebei Medical University Second Affiliated Hospital, Shijiazhuang, Hebei, P. R. China.

出版信息

J Int Med Res. 2021 Apr;49(4):3000605211009812. doi: 10.1177/03000605211009812.

DOI:10.1177/03000605211009812
PMID:33906528
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8108086/
Abstract

The incidence of tumours found in the patella, including primary and metastatic tumours, is low. Solitary metastasis of oesophageal carcinoma (OC) in the patella is even rarer. A 50-year-old man presented to our clinic because of pain and limited range of motion in the right knee for 4 hours and after a fall. On the basis of the patient's medical history, he was diagnosed with OC 2 months previously and underwent two cycles of paclitaxel liposome combined with tiggio chemotherapy (oral tiggio, 40 mg, two times/day, with a treatment cycle of 3 weeks). A 99mTc-methylene diphosphonate bone scintigraphy scan showed increased radioactivity in the right patella. A right knee biopsy showed the presence of patellar metastasis from OC. Unfortunately, the patient denied additional treatment and was discharged for personal reasons. At the 1-month follow-up, which was conducted by a telephone survey, we learned that the patient had died of acute pulmonary embolism. X-rays and computed tomography are useful for diagnosing patellar metastases, but 99mTc-methylene diphosphonate bone scintigraphy can help physicians diagnose patellar metastasis of OC more rapidly. Biopsy with pathology is the gold standard for diagnosing patellar metastases. Additionally, timely surgical treatment prolongs the survival time of these patients.

摘要

髌骨中发现的肿瘤,包括原发性和转移性肿瘤,发病率较低。髌骨中食管癌(OC)的孤立转移更为罕见。一名50岁男性因右膝疼痛和活动范围受限4小时,且此前有跌倒史,前来我院就诊。根据患者病史,他2个月前被诊断为OC,并接受了两个周期的紫杉醇脂质体联合替吉奥化疗(口服替吉奥,40mg,每日两次,治疗周期为3周)。99mTc-亚甲基二膦酸盐骨闪烁扫描显示右髌骨放射性增强。右膝活检显示存在来自OC的髌骨转移。不幸的是,患者因个人原因拒绝进一步治疗并出院。在通过电话调查进行的1个月随访中,我们得知患者死于急性肺栓塞。X线和计算机断层扫描对诊断髌骨转移有用,但99mTc-亚甲基二膦酸盐骨闪烁扫描可帮助医生更快地诊断OC的髌骨转移。病理活检是诊断髌骨转移的金标准。此外,及时的手术治疗可延长这些患者的生存时间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ed0/8108086/5f694d8519da/10.1177_03000605211009812-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ed0/8108086/b2c376b871d8/10.1177_03000605211009812-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ed0/8108086/bac3ec49ef18/10.1177_03000605211009812-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ed0/8108086/757b4b394640/10.1177_03000605211009812-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ed0/8108086/5f694d8519da/10.1177_03000605211009812-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ed0/8108086/b2c376b871d8/10.1177_03000605211009812-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ed0/8108086/bac3ec49ef18/10.1177_03000605211009812-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ed0/8108086/757b4b394640/10.1177_03000605211009812-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ed0/8108086/5f694d8519da/10.1177_03000605211009812-fig4.jpg

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