Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Science, Isfahan, Iran.
Gastrointestinal & Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Curr Med Chem. 2024;31(20):2944-2954. doi: 10.2174/0929867330666230413093409.
Neuroglobin (Ngb) is an oxygen-binding globin protein that is mainly expressed in the neurons of the central and peripheral nervous system. However, moderate levels of Ngb have also been detected in non-neural tissues. Ngb and Ngb modulating factors have been increasingly studied over the last decade due to their neuroprotective role in neurological disorders and hypoxia. Studies have shown that a number of chemicals, pharmaceuticals, and herbal compounds can modulate the expression of Ngb at different dose levels, indicating a protective role against neurodegenerative diseases. Iron chelators, hormones, antidiabetic drugs, anticoagulants, antidepressants, plant derivatives and short-chain fatty acids are among these compounds. Therefore, this study aimed to review the literature focused on the possible effects and mechanisms of chemical, pharmaceutical, and herbal compounds on Ngbs.
神经球蛋白（Ngb）是一种氧结合球蛋白蛋白，主要表达于中枢和外周神经系统的神经元中。然而，在非神经组织中也检测到了适度水平的 Ngb。由于其在神经疾病和缺氧中的神经保护作用，过去十年中，Ngb 和 Ngb 调节因子的研究日益增多。研究表明，许多化学物质、药物和草药化合物可以在不同剂量水平下调节 Ngb 的表达，表明其对神经退行性疾病具有保护作用。铁螯合剂、激素、抗糖尿病药物、抗凝剂、抗抑郁药、植物衍生物和短链脂肪酸都属于这些化合物。因此，本研究旨在综述关于化学物质、药物和草药化合物对 Ngbs 的可能作用和机制的文献。
