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FAR比值作为急性心肌梗死的预后生物标志物

FAR Ratio as Prognostic Biomarker in AMI.

作者信息

Muhtaroğlu Ali, Çapoğlu Recayi, Uygur Furkan Ali, Harmantepe Ahmet Tarık, Bayhan Zülfü, Gönüllü Emre

机构信息

Department of General Surgery, Giresun University Faculty of Medicine, Giresun University Training and Research Hospital, Aksu District, Mehmet İzmen Street, Number: 145, 28100 Giresun, PC Turkey.

General Surgery Clinic, Sakarya Training and Research Hospital, Adapazari, Turkey.

出版信息

SN Compr Clin Med. 2023;5(1):109. doi: 10.1007/s42399-023-01451-x. Epub 2023 Mar 22.

Abstract

Acute mesenteric ischemia (AMI) is a vascular emergency resulting from decreased blood flow caused by the occlusion of the mesenteric vessels, hypoperfusion, or vasospasm. This study aimed to investigate the prognostic value of the fibrinogen-to-albumin (FAR) ratio in patients with acute mesenteric ischemia. A total of 91 patients were enrolled in the study. Patients' demographics such as age and gender, pre- and postoperative hemoglobin, CRP, white blood cell (WBC), neutrophils, preoperative lymphocyte, alanine transaminase (ALT), aspartate transaminase (AST), thrombocytes, and postoperative D-dimer values were recorded. In addition, pre- and postoperative fibrinogen and albumin levels were recorded, and FAR was calculated. Patients were divided into two groups, survivors and non-survivors. The mean pre- and postoperative fibrinogen levels were statistically significantly higher in the non-survivor group than in the survivor group ( < 0.001). The mean pre- and postoperative albumin levels were significantly lower in the non-survivors than in the survivors ( = 0.059, < 0.001; respectively). The mean pre- and postoperative FAR ratios were considerably higher in the non-survivor than in the survivor groups ( < 0.001). The change between pre- and postoperative fibrinogen, albumin, and FAR values was statistically significant between the non-survivors and the survivors (for all, < 0.05). The preoperative and postoperative fibrinogen levels were significantly lower, and albumin levels were significantly higher in the survivor compared to the non-survivor patients with AMI. Furthermore, the preoperative and postoperative FAR ratio was significantly higher in the non-survivors. The FAR ratio may be a valuable prognostic biomarker for patients with AMI.

摘要

急性肠系膜缺血(AMI)是一种血管急症,由肠系膜血管阻塞、灌注不足或血管痉挛导致血流减少引起。本研究旨在探讨纤维蛋白原与白蛋白(FAR)比值对急性肠系膜缺血患者的预后价值。共有91例患者纳入本研究。记录患者的人口统计学特征,如年龄和性别、术前和术后血红蛋白、CRP、白细胞(WBC)、中性粒细胞、术前淋巴细胞、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、血小板以及术后D-二聚体值。此外,记录术前和术后纤维蛋白原和白蛋白水平,并计算FAR。患者分为两组,存活组和非存活组。非存活组术前和术后纤维蛋白原水平的平均值在统计学上显著高于存活组(<0.001)。非存活组术前和术后白蛋白水平的平均值显著低于存活组(分别为=0.059,<0.001)。非存活组术前和术后FAR比值的平均值显著高于存活组(<0.001)。非存活组和存活组之间术前和术后纤维蛋白原、白蛋白和FAR值的变化在统计学上具有显著性(所有P值均<0.05)。与非存活的AMI患者相比,存活患者术前和术后纤维蛋白原水平显著降低,白蛋白水平显著升高。此外,非存活组术前和术后FAR比值显著更高。FAR比值可能是AMI患者有价值的预后生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ebd/10031717/d4fa4ee2de23/42399_2023_1451_Fig1_HTML.jpg

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