Department of Neurology, Peking University Third Hospital, Beijing, 100191, China.
Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases, Beijing, China.
Sci Rep. 2021 Apr 27;11(1):9119. doi: 10.1038/s41598-021-88755-x.
Weight loss is common in patients with Amyotrophic lateral sclerosis (ALS), and associated with disease progression. Loss of appetite has been shown to be a contributor to weight loss in patients with amyotrophic lateral sclerosis (ALS). However, the reason of loss of appetite is not clear. The Council on Nutrition appetite questionnaire (CNAQ) and the simplified nutritional appetite questionnaire (SNAQ) are short and simple appetite assessment tools, which were using in ALS patients. In our study, the CNAQ and SNAQ were translated into Chinese, and their reliability and validity were tested. The Chinese version of the CNAQ (CNAQ-C) presented more appropriate reliability and validity than the SNAQ. Among the 94 ALS patients, 50 patients (53.2%) had loss of appetite, and we found that anxiety and/or depression contributed to the loss of appetite in the ALS patients. We reconfirmed that loss of appetite was associated with greater weight loss but not with clinical features of ALS. The loss of appetite caused by emotional problems in ALS patients should be taken seriously, and early intervention should be implemented to reduce weight loss.
体重减轻在肌萎缩侧索硬化症（ALS）患者中很常见，并且与疾病进展有关。已经表明，食欲下降是肌萎缩侧索硬化症（ALS）患者体重减轻的原因之一。但是，食欲下降的原因尚不清楚。营养食欲问卷（CNAQ）和简化营养食欲问卷（SNAQ）是两种简短而简单的食欲评估工具，已在 ALS 患者中使用。在我们的研究中，将 CNAQ 和 SNAQ 翻译成中文，并测试了其可靠性和有效性。CNAQ 的中文版（CNAQ-C）的可靠性和有效性均优于 SNAQ。在 94 名 ALS 患者中，有 50 名患者（53.2％）存在食欲下降，我们发现焦虑和/或抑郁会导致 ALS 患者的食欲下降。我们再次确认，食欲下降与体重减轻更大有关，而与 ALS 的临床特征无关。应认真对待 ALS 患者因情绪问题引起的食欲不振，并应及早进行干预以减少体重减轻。
