Australian Institute for Bioengineering and Nanotechnology, The University of Queensland , Brisbane , Australia.
Queensland Brain Institute, The University of Queensland , Brisbane , Australia.
Amyotroph Lateral Scler Frontotemporal Degener. 2019 Nov;20(7-8):497-505. doi: 10.1080/21678421.2019.1621346. Epub 2019 May 30.
: Weight loss in amyotrophic lateral sclerosis (ALS) is associated with faster disease progression and shorter survival. It has different possible causes, including loss of appetite. Our objective is to determine the prevalence and impact of loss of appetite on change in body weight and composition in patients with ALS. : We conducted a prospective case-control study, comparing demographic, clinical, appetite and prognostic features between 62 patients with ALS and 45 healthy non-neurodegenerative disease (NND) controls. To determine the impact of loss of appetite on weight throughout disease course, we conducted serial assessments at ∼three to four-month intervals. : Loss of appetite is more prevalent in patients with ALS than NND controls (29 vs. 11.1%, odds ratio = 3.27 (1.1-9.6); < 0.01). In patients with ALS, loss of appetite is associated with greater weight loss and greater loss of fat mass. Appetite scores in patients with ALS worsens as disease progresses and are correlated with worsening ALS Functional Rating Scale-Revised scores. : We confirm that loss of appetite is prevalent in patients with ALS and is significantly associated with weight loss and loss of fat mass. Appetite worsens with disease progression. Identification and early interventions to address loss of appetite in patients with ALS may prevent or slow weight loss; this could improve disease outcome.
肌萎缩侧索硬化症（ALS）患者的体重减轻与疾病进展更快和生存期更短有关。其可能有不同的原因，包括食欲下降。我们的目的是确定食欲下降对 ALS 患者体重和身体成分变化的影响。
我们进行了一项前瞻性病例对照研究，比较了 62 名 ALS 患者和 45 名健康非神经退行性疾病（NND）对照组的人口统计学、临床、食欲和预后特征。为了确定食欲下降对疾病过程中体重的影响，我们在大约每三到四个月进行一次连续评估。
食欲下降在 ALS 患者中比 NND 对照组更为常见（29%比 11.1%，比值比=3.27（1.1-9.6）；<0.01）。在 ALS 患者中，食欲下降与体重下降和脂肪量减少更多有关。ALS 患者的食欲评分随着疾病的进展而恶化，并且与 ALS 功能评定量表修订版评分的恶化相关。
我们证实，食欲下降在 ALS 患者中很常见，与体重减轻和脂肪量减少显著相关。随着疾病的进展，食欲恶化。在 ALS 患者中识别和早期干预食欲下降可能预防或减缓体重减轻，这可能改善疾病结局。
