Farouq Mohammed A H, Al Qaraghuli Mohammed M, Kubiak-Ossowska Karina, Ferro Valerie A, Mulheran Paul A
Department of Chemical and Process Engineering, University of Strathclyde, 75 Montrose Street, Glasgow, G1 1XJ, UK.
Department of Physics/Archie-West HPC, University of Strathclyde, 107 Rottenrow East, Glasgow, G4 0NG, UK.
Curr Opin Colloid Interface Sci. 2021 Aug;54:101461. doi: 10.1016/j.cocis.2021.101461. Epub 2021 Apr 23.
Nanoparticles are small particles sized 1-100 nm, which have a large surface-to-volume ratio, allowing efficient adsorption of drugs, proteins, and other chemical compounds. Consequently, functionalized nanoparticles have potential diagnostic and therapeutic applications. A variety of nanoparticles have been studied, including those constructed from inorganic materials, biopolymers, and lipids. In this review, we focus on recent work targeting the severe acute respiratory syndrome coronavirus 2 virus that causes coronavirus disease (COVID-19). Understanding the interactions between coronavirus-specific proteins (such as the spike protein and its host cell receptor angiotensin-converting enzyme 2) with different nanoparticles paves the way to the development of new therapeutics and diagnostics that are urgently needed for the fight against COVID-19, and indeed for related future viral threats that may emerge.
纳米颗粒是尺寸为1-100纳米的小颗粒，其具有大的表面积与体积比，能够有效吸附药物、蛋白质和其他化合物。因此，功能化纳米颗粒具有潜在的诊断和治疗应用。已经研究了多种纳米颗粒，包括由无机材料、生物聚合物和脂质构建的纳米颗粒。在本综述中，我们重点关注针对导致冠状病毒病（COVID-19）的严重急性呼吸综合征冠状病毒2病毒的近期研究工作。了解冠状病毒特异性蛋白（如刺突蛋白及其宿主细胞受体血管紧张素转换酶2）与不同纳米颗粒之间的相互作用，为开发对抗COVID-19以及未来可能出现的相关病毒威胁急需的新疗法和诊断方法铺平了道路。
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