Sacino Amanda, Rosenblatt Kathryn
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
J Neuroanaesth Crit Care. 2019;6(3):222-235. doi: 10.1055/s-0039-1694686. Epub 2019 Sep 13.
Spinal cord injury is devastating to those affected due to the loss of motor and sensory function, and, in some cases, cardiovascular collapse, ventilatory failure, and bowel and bladder dysfunction. Primary trauma to the spinal cord is exacerbated by secondary insult from the inflammatory response to injury. Specialized intensive care of patients with acute spinal cord injury involves the management of multiple systems and incorporates evidence-based practices to reduce secondary injury to the spinal cord. Patients greatly benefit from early multidisciplinary rehabilitation for neurologic and functional recovery. Treatment of acute spinal cord injury may soon incorporate novel molecular agents currently undergoing clinical investigation to assist in neuroprotection and neuroregeneration.
脊髓损伤对患者来说是毁灭性的，因为会导致运动和感觉功能丧失，在某些情况下还会引发心血管衰竭、呼吸衰竭以及肠道和膀胱功能障碍。脊髓的原发性创伤会因损伤炎症反应引起的继发性损伤而加剧。急性脊髓损伤患者的专业重症监护涉及多个系统的管理，并采用循证实践以减少脊髓的继发性损伤。早期多学科康复对患者的神经和功能恢复大有裨益。急性脊髓损伤的治疗可能很快会纳入目前正在进行临床研究的新型分子药物，以辅助神经保护和神经再生。
