Department of Veterinary Pharmacology and Research Center and Research Institute of Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
Farm Animal Clinical Training, College of Veterinary Medicine, Seoul National University, Seoul 08826, Korea.
J Vet Sci. 2021 May;22(3):e33. doi: 10.4142/jvs.2021.22.e33. Epub 2021 Mar 23.
Very virulent infectious bursal disease virus (vvIBDV) causes high mortality in chickens but measures to reduce the mortality have not been explored. Chickens (8-9 weeks) were treated with 3 agents before and during vvIBDV inoculation. Dexamethasone treatment reduced the mortality of infected chickens (40.7% vs. 3.7%; < 0.001), but treatment with aspirin or vitamin E plus selenium did not affect the mortality. The bursa of Fabricius appeared to have shrunk in both dead and surviving chickens ( < 0.01). The results indicate that dexamethasone can reduce mortality in vvIBDV-infected chickens and may provide therapeutic clues for saving individual birds infected by the virus.
非常强毒传染性法氏囊病病毒（vvIBDV）可引起鸡的高死亡率，但尚未探索降低死亡率的措施。在接种 vvIBDV 之前和期间，用 3 种药物处理鸡（8-9 周龄）。地塞米松处理可降低感染鸡的死亡率（40.7%比 3.7%；<0.001），但阿司匹林或维生素 E 加硒处理并不影响死亡率。法氏囊在死亡和存活的鸡中似乎都缩小了（<0.01）。结果表明，地塞米松可降低 vvIBDV 感染鸡的死亡率，并可能为挽救感染病毒的个体鸡提供治疗线索。
