Université Paris-Saclay, CNRS, BioCIS, 92290 Châtenay-Malabry, France.
Org Biomol Chem. 2021 Apr 28;19(16):3509-3526. doi: 10.1039/d1ob00153a.
The pyrido[1,2-a]indole unit found in many organic compounds such as natural products, pharmaceuticals, and materials, has intensively stimulated the research of new synthetic pathways giving access to this heterocyclic nucleus in very recent years. In this review, the synthesis of pyrido[1,2-a]indoles will be divided into two parts, which concern accesses to this skeleton using or not metal catalysis.
在许多有机化合物中都发现了吡啶并[1,2-a]吲哚单元,如天然产物、药物和材料等,这一结构单元近年来激发了人们对新的合成途径的研究,这些途径可以非常有效地构建这一杂环核。在这篇综述中,吡啶并[1,2-a]吲哚的合成将分为两部分,分别讨论了使用或不使用金属催化构建该骨架的方法。