一种用于固相多肽合成的光解羧基保护基。

Faculty of Environment & Life, Beijing University of Technology, Beijing, 100124, China.

Beijing Institute of Radiation Medicine, 27 Taiping Road, Haidian District, Beijing, 100850, China.

ChemistryOpen. 2021 Apr;10(4):497-502. doi: 10.1002/open.202000324.

A new kind of photolabile protecting group (PLPG) for carboxyl moieties was designed and synthesized as the linker between resin and peptide. This group can be used for the protection of amino acid carboxyl groups. The peptide was synthesized on Nph (2-hydroxy-3-(2-nitrophenyl)-heptanoic acid)-derivatized resins and could be cleaved under UV exposure, thus avoiding the necessity for harsh acid-mediated resin cleavage. The PLPG has been successfully used for solid-phase synthesis of peptides.

设计并合成了一种新型的光不稳定保护基团（PLPG）用于连接树脂和肽。该基团可用于保护氨基酸的羧基。该肽在 Nph（2-羟基-3-（2-硝基苯基）-庚酸）衍生的树脂上进行合成，并可在紫外光照射下裂解，从而避免了使用苛刻的酸介导的树脂裂解。该 PLPG 已成功用于肽的固相合成。