Key Laboratory of New Membrane Materials, Ministry of Industry and Information Technology, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, P. R. China.
Department of Chemistry, University of Warwick, Gibbet Hill CV4 7AL, U.K.
Biomacromolecules. 2021 May 10;22(5):2224-2232. doi: 10.1021/acs.biomac.1c00298. Epub 2021 Apr 28.
Cationic glycopolymers with structures similar to those of typical poly(ionic liquid)s (PILs) were synthesized the quaternization reaction of poly(4-vinyl pyridine) with halogen-functionalized d-mannose and tetraphenylethylene units. Such postpolymerization modification provided PILs with aggregation-induced emission effect as well as specific carbohydrate-protein recognition with lectins such as concanavalin A. The interactions between cationic glycopolymers and different microorganisms, including Gram-positive and Gram-negative , were used for the killing, imaging, and detection of bacteria. Besides, these sugar-containing PILs showed a relatively low hemolysis rate due to the presence of saccharide units, which may have potential application in the field of biomaterials.
阳离子糖聚合物的结构类似于典型的聚离子液体（PILs），通过聚 4-乙烯基吡啶与卤代功能化的 D-甘露糖和四苯乙烯单元的季铵化反应合成。这种聚合后修饰为 PILs 提供了聚集诱导发射效应，以及与凝集素（如伴刀豆球蛋白 A）的特定碳水化合物-蛋白质识别。阳离子糖聚合物与不同微生物（包括革兰氏阳性菌和革兰氏阴性菌）之间的相互作用用于细菌的杀伤、成像和检测。此外，由于存在糖单元，这些含糖 PILs 的溶血率相对较低，这可能使其在生物材料领域具有潜在的应用。
