Kiss I, Farsang C
2nd Department of Internal Medicine, Semmelweis Medical University, Budapest, Hungary.
Cor Vasa. 1988;30(2):105-9.
The calcium entry blocker nifedipine produces systemic vasodilation and decreases the elevated vascular resistance in hypertensive patients. The authors investigated the acute antihypertensive effect of sublingually administered nifedipine in two different formulas: Adalat capsules and Corinfar dragées. There was no significant difference between both these formulas regarding their effects on blood pressure and heart rate, and their side effects were also similar. The authors conclude that the acute antihypertensive effect of nifedipine, either in capsules or in dragées, is equipotent in essential hypertension.
钙通道阻滞剂硝苯地平可产生全身血管舒张作用，并降低高血压患者升高的血管阻力。作者研究了舌下含服两种不同剂型硝苯地平（拜新同胶囊和可力平糖衣片）的急性降压效果。这两种剂型在血压和心率影响以及副作用方面均无显著差异。作者得出结论，硝苯地平无论是胶囊剂型还是糖衣片剂型，在原发性高血压中具有同等的急性降压效果。
