[Disturbance of the mechanical integration of cells in tissues in the occurrence of spontaneous hepatomas and lung adenomas in mice].

The force (F) and coefficient of stability (Cst) of cell cohesion were measured in the liver parenchyma from CBA mice and in alveolar epithelium of the lung from A mice (genetically susceptible to spontaneous tumours) aged 1 to 13 months. Coefficients of F and Cst magnitude variation increase, while those of mean Cst decrease in animals aged 9 months in the both tissues. In spontaneous tumours F and Cst decrease more considerably. In the nontumour tissue near the tumours the Cst coefficient increases again, but the F coefficient remains low. The author considers that a decrease in the mechanical cell integration of the tissue is necessarily involved into the process of blastomogenesis and that a decrease of F stimulates the tumour promotion.