Chapman A G, Evans M C
J Neurochem. 1983 Sep;41(3):886-9. doi: 10.1111/j.1471-4159.1983.tb04823.x.
The rate of cortical gamma-aminobutyric acid (GABA) turnover was estimated by determining the rate of GABA accumulation following inhibition of GABA transaminase by gamma-vinyl-GABA (1.5 g/kg, i.v.) in paralysed, ventilated rats. During 1 h of bicuculline-induced seizures (1.2 mg/kg, i.v.) the rate of accumulation of cortical GABA level is approximately threefold greater than in the control group receiving gamma-vinyl-GABA alone, suggesting that the GABA shunt activity increases in parallel with the increase in overall cortical metabolic rate observed during bicuculline seizures. Pretreatment with gamma-vinyl-GABA did not affect the bicuculline-induced changes in other major cortical amino acids.
通过在麻痹、通气的大鼠中静脉注射γ-乙烯基-GABA（1.5 g/kg）抑制γ-氨基丁酸（GABA）转氨酶后，测定GABA积累速率来估算皮质GABA的转换率。在荷包牡丹碱诱导的癫痫发作（静脉注射1.2 mg/kg）1小时期间，皮质GABA水平的积累速率比仅接受γ-乙烯基-GABA的对照组大约高三倍，这表明GABA分流活性的增加与荷包牡丹碱癫痫发作期间观察到的整体皮质代谢率的增加平行。γ-乙烯基-GABA预处理不影响荷包牡丹碱诱导的其他主要皮质氨基酸的变化。
