Imam Faisal, Sharma Manju, Obaid Al-Harbi Naif, Rashid Khan Mohammad, Qamar Wajhul, Iqbal Muzaffar, Daud Ali Mohammad, Ali Nemat, Khalid Anwar Md
Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Department of Pharmacology, School of Pharmaceutical Education and Research, Hamdard University, New Delhi 110062, India.
Saudi J Biol Sci. 2021 Apr;28(4):2041-2048. doi: 10.1016/j.sjbs.2021.02.004. Epub 2021 Feb 14.
First-line antituberculosis (anti-TB) compounds have been considered as proven components of the Directly Observed Treatment-Short course (DOTS). Drug therapy against tuberculosis has been categorized as I, II, or III following the Revised National Tuberculosis Control Program guidelines. Anti-TB are drugs are quite common and show limited adverse effects. However, first-line anti-TB compounds mediated DOTS therapy and were found with several complications. Thus, those drugs have been discontinued. Therefore, the present study was designed to find out the possible impact of socioeconomic, income, and educational status on the adverse effects of drugs and their therapeutic episodes in patients targeted with a combination of tuberculosis intervention. This study found that an increased incidence of tuberculosis was found in patients who have finished high school, contributing to a high percentage of adverse effects. Notably, adverse events were shown maximally in poor patients compared with rich- or high-income patients. On the contrary, a high prevalence of adverse events was shown to be increased in partially skilled workers compared with full-skilled workers. Consequently, adversely considerable events were implicated to be raised in patients associated with minimal socioeconomic class. Such interesting factors would help in monitoring such events in experimental patients.
一线抗结核药物一直被视为直接观察短程治疗(DOTS)的已证实组成部分。根据修订后的国家结核病控制规划指南,抗结核药物治疗已分为I、II或III类。抗结核药物相当常见,且不良反应有限。然而,一线抗结核药物介导的DOTS治疗出现了一些并发症。因此,这些药物已被停用。因此,本研究旨在探讨社会经济、收入和教育状况对结核病综合干预目标患者药物不良反应及其治疗疗程的可能影响。本研究发现,完成高中学业的患者结核病发病率增加,不良反应比例较高。值得注意的是,与富裕或高收入患者相比,贫困患者的不良事件发生率最高。相反,与全技能工人相比,半熟练工人的不良事件发生率较高。因此,社会经济阶层最低的患者中不良事件的发生率也会相应增加。这些有趣的因素将有助于监测实验患者中的此类事件。