State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
Org Biomol Chem. 2021 Sep 14;19(34):7264-7275. doi: 10.1039/d1ob01248g. Epub 2021 Aug 17.
CpM(iii)-catalyzed enantioselective C-H functionalization reactions have progressed rapidly using either chiral cyclopentadienyl ligands or appropriate chiral carboxylic acids. In this context, highly reactive carbene and nitrene precursors can serve as effective C-H coupling partners, providing a straightforward and efficient approach to access chiral molecules. In this review, we highlight the developments in CpM(iii)-catalyzed enantioselective C-H functionalization reactions through migratory insertion of metal-carbenes/nitrenes by employing chiral CpM(iii) complexes or achiral CpM(iii) complexes combined with chiral carboxylic acids.
CpM(iii)-催化的对映选择性 C-H 功能化反应已经取得了快速进展，使用手性环戊二烯基配体或合适的手性羧酸。在这种情况下，高反应性的卡宾和氮宾前体可以作为有效的 C-H 偶联伙伴，为获得手性分子提供了一种直接有效的方法。在这篇综述中，我们通过使用手性 CpM(iii)配合物或非手性 CpM(iii)配合物与手性羧酸结合，强调了 CpM(iii)-催化的通过金属卡宾/氮宾迁移插入的对映选择性 C-H 功能化反应的发展。
