CpM(iii)-catalyzed enantioselective C-H functionalization through migratory insertion of metal-carbenes/nitrenes.

CpM(iii)-catalyzed enantioselective C-H functionalization reactions have progressed rapidly using either chiral cyclopentadienyl ligands or appropriate chiral carboxylic acids. In this context, highly reactive carbene and nitrene precursors can serve as effective C-H coupling partners, providing a straightforward and efficient approach to access chiral molecules. In this review, we highlight the developments in CpM(iii)-catalyzed enantioselective C-H functionalization reactions through migratory insertion of metal-carbenes/nitrenes by employing chiral CpM(iii) complexes or achiral CpM(iii) complexes combined with chiral carboxylic acids.