Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Drosophila Center for Human Diseases and Drug Discovery (DHD), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Wiley Interdiscip Rev RNA. 2021 Nov;12(6):e1661. doi: 10.1002/wrna.1661. Epub 2021 Apr 29.
In the last decade, an intriguing new paradigm of regulation has emerged in which some transcripts longer than 200 nucleotides and no coding potential, long noncoding RNA (lncRNAs), exhibit the capability to control posttranslational modifications of nonhistone proteins in both invertebrates and vertebrates. The extent of such a regulation is still largely unknown. We performed a systematic review to identify and evaluate the potential impact of lncRNA-dependent methylation of nonhistone proteins. Collectively, these lncRNAs primarily act as scaffolds upon which methyltransferases (MTases) and targets are brought in proximity. In this manner, the N-MTase activity of EZH2, protein arginine-MTase 1/4/5, and SMYD2 is exploited to modulate the stability or the compartmentalization of several nonhistone proteins with roles in cell signaling, gene expression, and RNA processing. Moreover, these lncRNAs can indirectly affect the methylation of nonhistone proteins by transcriptional or posttranscriptional regulation of MTases. Strikingly, the lncRNAs/MTases/nonhistone proteins networking seem to be relevant to carcinogenesis and neurological disorders. This article is categorized under: Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs.
在过去的十年中，出现了一种有趣的新调控模式，其中一些长度超过 200 个核苷酸且没有编码潜力的长非编码 RNA（lncRNA）能够在无脊椎动物和脊椎动物中控制非组蛋白蛋白质的翻译后修饰。这种调控的程度在很大程度上仍然未知。我们进行了系统评价，以确定和评估 lncRNA 依赖性非组蛋白蛋白质甲基化的潜在影响。总的来说，这些 lncRNA 主要作为甲基转移酶（MTases）和靶标的支架，使它们相互靠近。通过这种方式，EZH2、蛋白质精氨酸-MTase 1/4/5 和 SMYD2 的 N-MTase 活性被利用来调节几种非组蛋白蛋白质的稳定性或区室化，这些蛋白质在细胞信号转导、基因表达和 RNA 处理中发挥作用。此外，这些 lncRNA 可以通过 MTase 的转录或转录后调控间接影响非组蛋白蛋白质的甲基化。引人注目的是，lncRNA/MTase/非组蛋白蛋白质网络似乎与癌症发生和神经紊乱有关。本文归类于：调控 RNA/RNAi/核糖开关>调控 RNA。
