Department of Medical Genetics, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Hormozgan Institute of Health, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Hum Cell. 2022 Sep;35(5):1355-1363. doi: 10.1007/s13577-022-00733-1. Epub 2022 Jul 7.
Long non-coding RNA (LncRNA) is a new type of non-coding RNA whose transcription is more than 200 nucleotides in length and can be up to 100 kb. The crucial regulatory function of lncRNAs in different cellular processes is now notable in many human diseases, especially in different steps of tumorigenesis, making them clinically significant. This research tried to collect all evidence obtained so far regarding Nuclear Receptor subfamily 2 group F member 2 Antisense RNA 1 (NR2F2-AS1) to explore its role in carcinogenesis and molecular mechanism in several cancers. Collecting evidence value an oncogenic role for NR2F2-AS1, whose dysregulation changes the status for cancerous cells to gain the supremacy toward cellular proliferation, dissemination, and ultimately migration. The NR2F2-AS1 acts as competitive endogenous RNA (ceRNA) and contains several microRNA response elements (MREs) for different microRNAs involved in various pathways such as PI3K/AKT, Wnt/β-catenin, and TGF-β. This clinically makes NR2F2-AS1 a remarkable lncRNA which contributes to cancer progression and invasion and perhaps could be a candidate as a prognostic marker or even a therapeutic target.
长链非编码 RNA（lncRNA）是一种新型的非编码 RNA，其转录长度超过 200 个核苷酸，可达 100kb。lncRNAs 在不同细胞过程中的关键调节功能在许多人类疾病中已经很明显，尤其是在肿瘤发生的不同阶段，这使得它们具有重要的临床意义。本研究试图收集迄今为止关于核受体亚家族 2 组 F 成员 2 反义 RNA 1（NR2F2-AS1）的所有证据，以探讨其在几种癌症中的致癌作用及其分子机制。有证据表明 NR2F2-AS1 具有致癌作用，其失调改变了癌细胞的状态，使其获得了在细胞增殖、扩散和最终迁移方面的优势。NR2F2-AS1 作为竞争性内源性 RNA（ceRNA），包含几个 microRNA 反应元件（MREs），用于涉及不同途径的 microRNA，如 PI3K/AKT、Wnt/β-catenin 和 TGF-β。这使得 NR2F2-AS1 在临床上成为一种显著的 lncRNA，它有助于癌症的进展和侵袭，也许可以作为一个候选的预后标志物，甚至是一个治疗靶点。
