CRIOBE, USR EPHE-UPVD-CNRS 3278, Université de Perpignan Via Domitia, 58 Avenue Paul Alduy, Perpignan 66860, France.
Laboratoire d'Excellence "CORAIL", 58 Avenue Paul Alduy, Perpignan 66860, France.
J Med Chem. 2021 May 13;64(9):6198-6208. doi: 10.1021/acs.jmedchem.1c00249. Epub 2021 Apr 29.
In the marine environment, sessile cyanobacteria have developed chemical strategies for protection against grazers. In turn, herbivores have to circumvent these defenses and in certain cases even take advantage of them as shelter from their own predators. This is the case of , a sea hare that feeds on , a cyanobacterium that produces toxic cyclic lipopeptides of the laxaphycin B family. consumes the cyanobacterium without being affected by the toxicity of its compounds and also uses it as an invisibility cloak against predators. In this article, using different substrates analogous to laxaphycin B, we demonstrate the presence of an enzyme in the digestive gland of the mollusk that is able to biotransform laxaphycin B derivatives. The enzyme belongs to the poorly known family of d-peptidases that are suspected to be involved in antibiotic resistance.
在海洋环境中，固着蓝藻已经发展出了化学策略来抵御食草动物。反过来，草食动物必须规避这些防御，在某些情况下，甚至利用它们作为躲避自身捕食者的庇护所。这就是海兔的情况，它以产生松弛菌素 B 家族毒性环状脂肽的蓝藻为食。海兔食用蓝藻而不受其化合物毒性的影响，还将其用作躲避捕食者的隐形斗篷。在本文中，我们使用与松弛菌素 B 类似的不同底物，证明了软体动物的消化腺中存在一种能够生物转化松弛菌素 B 衍生物的酶。该酶属于鲜为人知的 d-肽酶家族，该家族被怀疑与抗生素耐药性有关。
