Lee Chia-Yi, Yang Shun-Fa, Mai Elsa Lin-Chin, Huang Jing-Yang, Yeh Chao-Bin, Chang Chao-Kai
Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
Nobel Eye Institute, Taipei 10041, Taiwan.
Diagnostics (Basel). 2025 Mar 18;15(6):760. doi: 10.3390/diagnostics15060760.
: This study aimed to investigate the possible relationship between aortic stenosis (AS) occupancy and the incidence of subsequent macular diseases. : A retrospective cohort study was conducted using the TriNetX database, and participants with AS were enrolled and matched to non-AS participants. A total of 421,860 and 421,860 participants were evenly divided into the AS and non-AS groups, respectively. The major outcomes of the present study include the development of age-related macular degeneration (AMD), retinal vascular occlusion (RVO), epiretinal membrane (ERM), and central serous chorioretinopathy (CSC). Cox proportional hazard regression was utilized for statistical analysis. : There were 4426 and 3013 AMD events; 7315 and 4753 RVO events; 2780 and 1910 ERM events; and 113 and 64 CSC events in the AS and non-AS groups, respectively. According to the results of Cox proportional hazard regression analysis, the AS group demonstrated significantly higher incidences of all macular diseases, including AMD, RVO, ERM, and CSC, compared to the non-AS group (all < 0.05). The cumulative probabilities of all macular diseases were significantly higher in the AS group than in the non-AS group (all < 0.05). In the sensitivity analysis, the developmental risks of AMD were significantly higher in the AS group than in the non-AS group with all traits. : This study determined that AS occupancy is related to a higher risk of developing macular diseases, which positively correlated to the disease time of AS.
本研究旨在探讨主动脉瓣狭窄（AS）患病率与随后黄斑疾病发病率之间的可能关系。使用TriNetX数据库进行了一项回顾性队列研究，纳入了患有AS的参与者并与非AS参与者进行匹配。总共421860名参与者被平均分为AS组和非AS组，每组各421860人。本研究的主要结局包括年龄相关性黄斑变性（AMD）、视网膜血管阻塞（RVO）、视网膜前膜（ERM）和中心性浆液性脉络膜视网膜病变（CSC）的发生情况。采用Cox比例风险回归进行统计分析。AS组和非AS组分别有4426例和3013例AMD事件；7315例和4753例RVO事件；2780例和1910例ERM事件；以及113例和64例CSC事件。根据Cox比例风险回归分析结果，与非AS组相比，AS组所有黄斑疾病的发病率均显著更高，包括AMD、RVO、ERM和CSC（均P<0.05）。AS组所有黄斑疾病的累积概率均显著高于非AS组（均P<0.05）。在敏感性分析中，AS组AMD的发病风险在所有特征方面均显著高于非AS组。本研究确定AS患病率与黄斑疾病发生风险较高相关，且与AS的病程呈正相关。
