Laboratory of Biotechnologies and Valorization of Natural Resources, Faculty of Sciences, University Ibn Zhor, 80060, Agadir, Morocco.
Natural products, Analysis, Synthesis, UMR CNRS 8038 CiTCoM, Faculty of Pharmacy, University of Paris, 75006, Paris, France.
Chem Biodivers. 2021 Jun;18(6):e2100115. doi: 10.1002/cbdv.202100115. Epub 2021 May 26.
The chemical composition and in vitro antibacterial and cytotoxic activities of the essential oil (EO) of Chiliadenus antiatlanticus (Emb. & Maire) Gómiz, an asteraceous species endemic to the southwest of Morocco, were investigated. The EO yield was 1.07±0.28 %, twenty-seven metabolites were identified representing more than 96.4 % of the total composition. Camphor (35.7 %) and derivatives, borneol (4.9 %) and camphene (4.2 %) together with intermedeol (19.9 %), α-pinene (15.5 %) and (E)-pinocarveol (4.1 %) were the major constituents. An antibacterial activity was noticed against 24 strains (all Gram-positive) out of 71 at MICs values=100 μg/mL. The EO also showed significant toxicity towards liver HepG2 (55.8 % of cell viability) and melanoma B16 4A5 (41.6 % of cell viability) tumor cell lines at 100 μg/mL.
研究了摩洛哥西南部特有植物 Chiliadenus antiatlanticus（Emb. & Maire）Gómiz 的挥发油（EO）的化学成分及其体外抗菌和细胞毒性活性。EO 的产率为 1.07±0.28%，鉴定出二十七种代谢产物，占总成分的 96.4%以上。樟脑（35.7%）及其衍生物、龙脑（4.9%）和莰烯（4.2%）以及异松油烯（19.9%）、α-蒎烯（15.5%）和（E）-松油醇（4.1%）是主要成分。对 71 株菌中的 24 株（均为革兰氏阳性菌）进行了 MICs 值=100μg/mL 的抗菌活性测试。在 100μg/mL 时，EO 对肝癌 HepG2（55.8%的细胞活力）和黑色素瘤 B16 4A5（41.6%的细胞活力）肿瘤细胞系也表现出显著的毒性。
