Köse Yavuz Bülent, İşcan Gökalp, Göger Fatih, Akalın Gülşen, Demirci Betül, Başer Kemal Hüsnü Can
Department of Pharmaceutical Botany, Faculty of Pharmacy, Anadolu University, TR-26470, Eskisehir.
Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, TR-26470, Eskisehir.
Chem Biodivers. 2016 Oct;13(10):1369-1379. doi: 10.1002/cbdv.201600070.
The genus Centaurea L. is one of the largest and important genera of Asteraceae family. Centaurea species have been widely used as herbal remedies in folk medicine for their antidandruff, antidiarrheic, antirheumatic, anti-inflammatory, choleretic, diuretic, digestive, stomachic, astringent, antipyretic, cytotoxic, and antibacterial properties. Centaurea baseri Kose & Alan is a recently described local endemic species in Turkey and this is the first study on the chemical composition and bioactivity of its hydrodistilled essential oil and the crude extract. According to chromatospectral analysis, hexadecanoic acid (42.3%), nonacosane (8.2%), and heptacosane (8.0%) were the main compounds of the essential oil, while 16 compounds were determined in the MeOH extract using LC/MS. Furthermore, antimicrobial, antioxidant, and cytotoxic effects of the essential oil and the extract were evaluated in comparison with the standard agents. The extract showed strong antifungal effect against Candida utilis at the concentration of 60 μg/ml (MIC) where the EO showed growth inhibition at the concentration of 47.00 μg/ml (MIC) against pathogen Bacillus cereus. Both the essential oil and the extract did not show any selective antioxidant properties. The extract showed remarkably selective cytotoxic properties against MCF-7, PANC-1, A549, and C6 glioma cells.
矢车菊属（Centaurea L.）是菊科最大且重要的属之一。矢车菊属植物因其具有去屑、止泻、抗风湿、抗炎、利胆、利尿、助消化、健胃、收敛、退热、细胞毒性和抗菌特性，在民间医学中被广泛用作草药。巴塞尔矢车菊（Centaurea baseri Kose & Alan）是土耳其最近描述的一种地方特有物种，这是对其水蒸馏精油和粗提物的化学成分及生物活性的首次研究。根据色谱分析，十六烷酸（42.3%）、二十九烷（8.2%）和二十七烷（8.0%）是精油的主要成分，而使用液相色谱/质谱法在甲醇提取物中鉴定出了16种化合物。此外，将精油和提取物的抗菌、抗氧化和细胞毒性作用与标准试剂进行了比较评估。提取物在浓度为60μg/ml（最低抑菌浓度）时对产朊假丝酵母显示出较强的抗真菌作用，而精油在浓度为47.00μg/ml（最低抑菌浓度）时对病原菌蜡样芽孢杆菌显示出生长抑制作用。精油和提取物均未表现出任何选择性抗氧化特性。提取物对MCF - 7、PANC - 1、A549和C6胶质瘤细胞显示出显著的选择性细胞毒性特性。
