Schuller E, Delasnerie N
Pathol Biol (Paris). 1977 Sep;25(7):485-92.
CSF immunological reactions are classified in 5 patterns, considering the level of CSF albumin and the percentage of CSF-IgG. The 5 patterns are: 1) normal, 2) inflammatory (pure local synthesis of IgG), 3) two types of trasudates (inflammatory or not) when blood-CSF exchanges increase, 4) meningitis if a transudate is associated with local IgG synthesis. The distinction between transudate and meningitis needs the determination of serum IgG. This classification better than the classical ratios, defines the immunological status of a neurological patient in the different phases of his disease. It determines the frequency of the 5 immunological patterns for each nervous disease and the signification of any antibody detected in the CSF. It proposes a common language between the different laboratories and overall, between biologists and clinicians.
考虑到脑脊液白蛋白水平和脑脊液IgG百分比，脑脊液免疫反应分为5种模式。这5种模式为：1）正常，2）炎症性（IgG单纯局部合成），3）当血脑脊液交换增加时的两种漏出液（炎症性或非炎症性），4）如果漏出液与局部IgG合成相关则为脑膜炎。漏出液和脑膜炎的区分需要测定血清IgG。这种分类比经典比值更好，它定义了神经疾病患者在其疾病不同阶段的免疫状态。它确定了每种神经疾病的5种免疫模式的频率以及脑脊液中检测到的任何抗体的意义。它在不同实验室之间，总体而言，在生物学家和临床医生之间提供了一种通用语言。
