Domingo J L, Gomez M, Sanchez D J, Llobet J M, Corbella J
Laboratory of Toxicology and Biochemistry, School of Medicine, University of Barcelona, Reus, Spain.
Res Commun Chem Pathol Pharmacol. 1993 Mar;79(3):377-80.
The influence of some frequent dietary constituents on gastrointestinal absorption of aluminum from drinking water and diet was investigated in mice. Eight groups of male mice received lactic (57.6 mg/kg/day), tartaric (96 mg/kg/day), gluconic (125.4 mg/kg/day), malic (85.8 mg/kg/day), succinic (75.6 mg/kg/day), ascorbic (112.6 mg/kg/day), citric (124 mg/kg/day), and oxalic (80.6 mg/kg/day) acids in the drinking water for one month. At the end of this period, animals were killed and aluminum concentrations in liver, spleen, kidney, brain, and bone were determined. All the dietary constituents significantly increased the aluminum levels in bone, whereas brain aluminum concentrations were also raised by the intake of lactic, gluconic, malic, citric, and oxalic acids. The levels of aluminum found in spleen were significantly increased by gluconic and ascorbic acids, whereas gluconic and oxalic acids also raised the concentrations of aluminum found in kidneys. Because of the wide presence and consumption of the above dietary constituents, in order to prevent aluminum accumulation and toxicity we suggest a drastic limitation of human exposure to aluminum.
在小鼠中研究了一些常见饮食成分对饮用水和食物中铝的胃肠道吸收的影响。八组雄性小鼠连续一个月饮用含有乳酸（57.6毫克/千克/天）、酒石酸（96毫克/千克/天）、葡萄糖酸（125.4毫克/千克/天）、苹果酸（85.8毫克/千克/天）、琥珀酸（75.6毫克/千克/天）、抗坏血酸（112.6毫克/千克/天）、柠檬酸（124毫克/千克/天）和草酸（80.6毫克/千克/天）的水。在这一时期结束时，处死动物并测定肝脏、脾脏、肾脏、大脑和骨骼中的铝浓度。所有饮食成分均显著提高了骨骼中的铝含量，而饮用含有乳酸、葡萄糖酸、苹果酸、柠檬酸和草酸的水也会提高大脑中的铝浓度。葡萄糖酸和抗坏血酸显著提高了脾脏中的铝含量，而葡萄糖酸和草酸也提高了肾脏中的铝浓度。由于上述饮食成分广泛存在且被大量食用，为防止铝的蓄积和毒性，我们建议大幅限制人类对铝的接触。
