Department of Ophthalmology and Visual Science, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.
Hospital Universiti Sains Malaysia, Jalan Raja Perempuan Zainab 2, Kota Bharu 16150, Kelantan, Malaysia.
Int J Environ Res Public Health. 2021 Jul 1;18(13):7054. doi: 10.3390/ijerph18137054.
Retinopathy of prematurity (ROP) is a proliferative retinal vascular disorder attributed to an ischaemic stimulus in preterm infants. Haemoglobin, the main component for oxygen transportation, may be implicated in ROP development. This retrospective study compared the mean weekly haemoglobin levels between infants with and without ROP over the first six weeks of life. Premature infants of less than 32 weeks gestational age and less than 1.5 kg birth weight were grouped into age and birth weight-matched ROP cases and controls. Weekly mean haemoglobin levels were documented. An independent t-test was used to analyze the difference in mean haemoglobin levels between infants with ROP and infants without ROP. Adjustment for confounders was performed using one-way analysis of covariance. There was a statistically significant difference in adjusted mean haemoglobin levels between the ROP and non-ROP group during the first week of life ( = 0.038). No significant intergroup differences were observed at the other weeks. Haemoglobin monitoring during the first week of postnatal life may be useful to guide ROP screening in premature infants.
早产儿视网膜病变（ROP）是一种增生性视网膜血管疾病，归因于早产儿的缺血刺激。血红蛋白是运输氧气的主要成分，可能与 ROP 的发展有关。这项回顾性研究比较了生命的前 6 周内患有和不患有 ROP 的婴儿的平均每周血红蛋白水平。将胎龄小于 32 周且出生体重小于 1.5 公斤的早产儿分为年龄和出生体重匹配的 ROP 病例和对照组。记录每周平均血红蛋白水平。使用独立 t 检验分析 ROP 婴儿和无 ROP 婴儿之间平均血红蛋白水平的差异。使用单因素协方差分析对混杂因素进行调整。在生命的第一周，ROP 组和非 ROP 组之间的调整平均血红蛋白水平存在统计学显著差异（ = 0.038）。在其他几周没有观察到显著的组间差异。在生命的第一周监测血红蛋白可能有助于指导早产儿的 ROP 筛查。
